Results 41 to 50 of about 105,097 (295)

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Guiding Evacuees to Improve Fire Building Evacuation Efficiency: Hazard and Congestion Models to Support Decision Making by a Context-Aware Recommender System

Buildings, 2023
Fires in large buildings can have tragic consequences, including the loss of human lives. Despite the advancements in building construction and fire safety technologies, the unpredictable nature of fires, particularly in large buildings, remains an ...
Joaquim Neto, António Jorge Morais, Ramiro Gonçalves, António Leça Coelho   +3 more
doaj   +1 more source

Information requirements for enterprise systems [PDF]

, 2012
In this paper, we discuss an approach to system requirements engineering, which is based on using models of the responsibilities assigned to agents in a multi-agency system of systems.
A. Dardenne, F. Redmill, G. Baxter, I. Sommerville, I. Sommerville, J.E. Dobson, M. Glinz, R.E. Giachetti, S. Robertson   +8 more
core   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Social distance integrated gravity model for evacuation destination choice

International Journal of Digital Earth, 2021
Evacuation is an effective and commonly taken strategy to minimize death and injuries from an incoming hurricane. For decades, interdisciplinary research has contributed to a better understanding of evacuation behavior.
Yuqin Jiang, Zhenlong Li, Susan L. Cutter   +2 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

A comparison between model-based evacuation times and experimental data [PDF]

Bezpieczeństwo i Technika Pożarnicza, 2018
Purpose: The aim of this article was to compare the evacuation times obtained from public buildings, using selected mathematical models, with times of evacuations carried out experimentally.Introduction: In the article, various mathematical models are ...
Iwona Orłowska, Marek Dziubiński
doaj   +1 more source

Invisible control of self-organizing agents leaving unknown environments [PDF]

, 2016
In this paper we are concerned with multiscale modeling, control, and simulation of self-organizing agents leaving an unknown area under limited visibility, with special emphasis on crowds.
Albi, Giacomo, Bongini, Mattia, Cristiani, Emiliano, Kalise, Dante   +3 more
core   +3 more sources

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

An improved multi-velocity cellular automaton model that considers psychological impatience

Journal of Safety Science and Resilience
The cellular automaton (CA) model is an essential tool for studying pedestrian evacuation dynamics; moreover, improving simulations of actual evacuation environments and increasing the reliability of evacuation data are important problems for researchers.
Hongpeng Qiu, Wenke Zhang, Meng Shi, Eric Wai Ming Lee   +3 more
doaj   +1 more source