Results 131 to 140 of about 3,383,324 (311)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Chicago Summer Institute 2012 - Evaluating Sources
, 2014 Why Sources Matter? -- Spring 2012 Lecture NotesA PDF file of the PowerPoint presentation for the lesson on "Why Sources Matter?" Topics include: judging the reliability of sources, independent sources, anonymous sources, authoritative/informed sources ...
Stony Brook University. School of Journalism. Center for News Literacy.
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Challenges of evaluating the information visualization experience [PDF]
, 2007 Information Visualisation (InfoVis) is defined as an interactive visual representation of abstract data. We view the user’s interaction with InfoVis tools as an experience which is made up of a set of highly demanding cognitive activities.
Faisal, S., Cairns, P., Blandford, A.
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Designing and evaluating circular innovations from a responsible innovation perspective
, 2023 Organisations increasingly adopt circular principles when (re-) developing products and services. However, the socio-ethical aspects are often ignored despite the promise of products to safeguard our environment.
Ooi, Yat Ming, Chen, Sitong
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Evaluating gender mainstreaming in development projects
, 2006 Gender mainstreaming was established in the 1995 Beijing Platform for Action as a major strategy for the promotion of gender equality. As a development strategy, gender mainstreaming requires attention to gender perspectives, making them visible and ...
de Waal, Maretha
core +1 more source
Evaluating the coupling coordination between Healthy Beijing initiative and economic development
Frontiers in Public HealthBackground and objectiveHealth and economic development are pivotal elements underpinning societal progress, with intricate mutual influences. Under China’s “Healthy China” Initiative, the “Healthy Beijing Initiative” plays a crucial role in promoting ...
Xi Wang +5 more
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source