Results 191 to 200 of about 4,735,973 (246)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Targeted ALK inhibition achieving tumour control in metastatic melanoma: a case report. [PDF]

Acta Oncol
Schuster C, Oppedal IA, Vinnem LI, Abrahamsson EL, Barrett TM, Steinskog ESS, Giercksky Russnes HE, Helland Å.   +7 more
europepmc   +1 more source

Toward a mixed-methods framework for evaluating digital health systems in low-resource settings: an infrastructure-aware perspective. [PDF]

Front Digit Health
Nyatuka RD, Cherinet P, Jabin MSR.
europepmc   +1 more source

A pilot evaluation of ChatGPT-4o-assisted hypothesis generation for exploring potential links between fungal biology and cervical cancer. [PDF]

Antonie Van Leeuwenhoek
Li Y, Gu T, Ma L, Yao L, Li M, Han S, Li X, Gu W, Ma J.   +8 more
europepmc   +1 more source

Practical Guide to Large Language Models for Information Extraction in Behavioral Health Notes: Tutorial. [PDF]

JMIR Ment Health
Saha D, Edgcomb JB.
europepmc   +1 more source