Results 221 to 230 of about 18,898,156 (333)

IEA Inception Report: Annexes [PDF]

, 2015
CGIAR Independent Evaluation Arrangement
core  

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Embedded Research in a Learning Health System: How a Research-Operations Partnership Informed the Development, Implementation, and Scaling of VA's Whole Health System. [PDF]

Learn Health Syst
Bolton R, Zeliadt SB, Hyde J, Etingen B, Anderson E, Barker A, Wu J, Kligler B, Bokhour BG.   +8 more
europepmc   +1 more source

IEA 2013 Activity Report [PDF]

, 2014
CGIAR Independent Evaluation Arrangement
core  

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Correction to "Evaluation of ImpENSA Technology-Enabled Behaviour Change Module Delivered to Healthcare Professionals in South Africa to Improve Micronutrient Nutrition During the First 1000 Days". [PDF]

Matern Child Nutr
europepmc   +1 more source

A Scoping Review of Noncommunicable Disease Programs Evaluation: Bridging Gaps and Improving Frameworks in Primary Healthcare. [PDF]

Health Sci Rep
Marvi A, Sadeghi M, Aarabi M, Shabanikiya H, Kokabisaghi F, Houshmand E, Vafaee-Najar A.   +6 more
europepmc   +1 more source

School food standards in the UK: implementation and evaluation [PDF]

, 2013
Ashley Adamson, Suzanne Spence, Lowri Reed, Ruth Conway, A. W. Palmer, Eve Stewart, J. McBratney, Lynne Carter, Shirley Beattie, Michael Nelson   +9 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Evaluating the Tidda Talk Program: A Culturally Relevant Approach to Assessing Social and Emotional Wellbeing in Young Aboriginal and Torres Strait Islander Women. [PDF]

Health Promot J Austr
English M, Canuto K, Manton D, Fricker C, Wilson J, Caperchione CM.   +5 more
europepmc   +1 more source