Results 291 to 300 of about 17,544,570 (361)

Beyond cytotoxic T cells: reprogrammed regulatory T cells help facilitate response to dual checkpoint blockade

Molecular Oncology, EarlyView.
Rolig, Peng, and colleagues have shed new light on how dual blockade of PD1 and LAG3 enhances antitumor immunity. They found that response to immunotherapy with anti‐PD1 + anti‐LAG3 was associated with reprogramming of canonically suppressive CD4+ regulatory T cells to an inflammatory state.
Tullia C. Bruno, Anthony R. Cillo
wiley   +1 more source

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

Molecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková, Marie Ehrlichová, Alžběta Spálenková, Ivona Krus, Simona Šůsová, Viktor Hlaváč, Vlasta Němcová, Renata Koževnikovová, Markéta Trnková, David Vrána, Jiří Gatěk, Kateřina Kopečková, Marcela Mrhalová, Soňa Měšťáková, Pavel Souček   +14 more
wiley   +1 more source

Correction to: A safety and effectiveness evaluation of RefluxStop in the treatment of acid reflux comparing large and small hiatal hernia groups: results from 99 patients in Switzerland with up to 4-years follow-up. [PDF]

Hernia
Borbély Y, Kroell D, Gerber S, Fringeli Y, Linas I, Zehetner J.   +5 more
europepmc   +1 more source

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

Molecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim, Sungwoo Bae, Jaeyong Choi, Sun‐Wha Im, Bukyoung Cha, Gyeongseo Jung, Sun Wook Cho, Eul‐Ju Seo, Young Ah Lee, Jin Chul Paeng, Young Joo Park, Jong‐Il Kim   +11 more
wiley   +1 more source

A multi-level fuzzy comprehensive evaluation model to optimize biochar application schemes for potato cultivation in North China. [PDF]

Front Plant Sci
Guo J, Zhou H, Jia L, Wang Y, Fan M, Wang M, Liu P, Shang Z.   +7 more
europepmc   +1 more source

Logic models for the evaluation of complex interventions in public health: lessons learnt from a staged development process. [PDF]

BMC Public Health
Voss S, Bauer J, Coenen M, Jung-Sievers C, Moore G, Rehfuess E.   +5 more
europepmc   +1 more source

Correlation between Plane Assessment of Prolapse Degree and Pelvic Organ Prolapse Quantification Scores after Three-Dimensional Reconstruction of Female Pelvic Organ Prolapse.

Gynecol Obstet Invest
Shen L, Bai H, Sun X, Liu P, Chen C.
europepmc   +1 more source

Risk identification of coal and gas outburst based on improved CUOWGA weighting TOPSIS model. [PDF]

Sci Rep
Wang L, Jia B, Su G.
europepmc   +1 more source

Podcasts as a platform for sharing and disseminating experiences and expertise between young adults with cancer and radiotherapy researchers. [PDF]

Res Involv Engagem
Whittaker L, Espinosa-Cabrera E, Haar H, Hall E, Lambert S, Tristram J, Vladykova M, Drake R, Eminowicz G, Lewandowska P, Veiga C, Webster A, McNamara J, Julka-Anderson N, Owen D, Taylor-Gee A, Terry SYA, Dean JA.   +17 more
europepmc   +1 more source