Results 71 to 80 of about 17,544,570 (361)

Mycoplasma - contamination of cell cultures

Биопрепараты: Профилактика, диагностика, лечение, 2018
The safety of biological products derived from animal cells is associated with the properties of the cells themselves or their components, as well as with the possible presence of contaminants of microbial and viral origin.
N. V. Shalunova, R. A. Volkova, A. R. Volgin, E. M. Petruchuk, Z. E. Berdnikova, E. V. Elbert, V. A. Shevtsov, A. V. Rukavishnikov, I. S. Semenova, O. V. Merkulova, G. A. Trusov, N. V. Tereshkina, O. A. Rachinskaj, I. N. Indikova, E. V. Lebedinskaya, E. D. Mytsa   +15 more
doaj  

Health effects associated with chewing tobacco: a Burden of Proof study

Nature Communications
Chewing tobacco use poses serious health risks; yet it has not received as much attention as other tobacco-related products. This study synthesizes existing evidence regarding the health impacts of chewing tobacco while accounting for various sources of ...
Gabriela F. Gil, Jason A. Anderson, Aleksandr Aravkin, Kayleigh Bhangdia, Sinclair Carr, Xiaochen Dai, Luisa S. Flor, Simon I. Hay, Matthew J. Malloy, Susan A. McLaughlin, Erin C. Mullany, Christopher J. L. Murray, Erin M. O’Connell, Chukwuma Okereke, Reed J. D. Sorensen, Joanna Whisnant, Peng Zheng, Emmanuela Gakidou   +17 more
doaj   +1 more source

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

FEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg, Laura De Cnop, Bernd Nidetzky   +2 more
wiley   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

P‐glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells

FEBS Letters, EarlyView.
To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche, John R. Riordan, Burkhard Tümmler   +2 more
wiley   +1 more source

Characterization for the Similarity Assessment Between the Proposed Biosimilar SB17 and Ustekinumab Reference Product Using State-of-the-Art Analytical Methods

Drugs in R&D
Background SB17 is being developed as a biosimilar to ustekinumab reference product (RP), a human monoclonal antibody (IgG1 kappa immunoglobulin) that binds to the common p40 subunit of cytokines interleukin (IL)-23 and IL-12.
Sung-Yong Yang, Changsoo Lee, Keumbi Hwang, Jungmin Lee, Jaell Lee, Juyong Hong, Seongyoung Jung   +6 more
doaj   +1 more source

Evaluation of Insecticides for the Management of Litchi Fruit and Shoot Borer [PDF]

, 2020
Litchi is an important subtropical evergreen fruit crop grown in Nepal, which have high nutritive value and refreshing taste. The Litchi growers are experiencing severe loss every year with the damage caused by several insect pests.
Aryal, S. (Sunil), Bhusal, B. (Bikash), Chaudhary, B. (Bedanand), Upadhyay, S. K. (Sudeep)   +3 more
core  

Safety evaluation of intra-arterial cell delivery in stroke patients—a framework for future trials [PDF]

, 2019
Effective treatments are not yet available for the majority of stroke patients despite the significant advances in acute stroke management and care evident since the advent of therapeutic recanalization in 2015.
Boltze, Johannes, Jolkkonen, Jukka
core   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source