Results 71 to 80 of about 15,954,475 (309)

Health effects associated with chewing tobacco: a Burden of Proof study

Nature Communications
Chewing tobacco use poses serious health risks; yet it has not received as much attention as other tobacco-related products. This study synthesizes existing evidence regarding the health impacts of chewing tobacco while accounting for various sources of ...
Gabriela F. Gil, Jason A. Anderson, Aleksandr Aravkin, Kayleigh Bhangdia, Sinclair Carr, Xiaochen Dai, Luisa S. Flor, Simon I. Hay, Matthew J. Malloy, Susan A. McLaughlin, Erin C. Mullany, Christopher J. L. Murray, Erin M. O’Connell, Chukwuma Okereke, Reed J. D. Sorensen, Joanna Whisnant, Peng Zheng, Emmanuela Gakidou   +17 more
doaj   +1 more source

International Approaches to Regulation of Medicinal Products Containing Viable Human Cells

Биопрепараты: Профилактика, диагностика, лечение, 2018
The intensive development of cellular technologies stipulates the introduction at the global level of medicinal products based on viable human cells, which in most countries are referred to as biomedical cell products. The authors conducted a comparative
E. V. Melnikova, A. A. Goryaev, M. V. Savkina, O. V. Merkulova, A. A. Chaplenko, O. A. Rachinskaya, I. S. Semenova, G. A. Trusov, V. A. Merkulov   +8 more
doaj   +1 more source

The Fate (Outcome) of Clinically Apparent Single Lesion and Oligofocal Nephroblastomatosis Treated According to SIOP/GPOH Protocols for Wilms Tumor

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background The management of clinically apparent single lesions or oligofocal nephroblastomatosis, a facultative precursor of nephroblastoma, remains debated. Methods We retrospectively analyzed 37 patients with clinically apparent single or oligofocal nephroblastomatosis (two to three lesions per kidney) among 2347 patients registered between
Nils Welter, Jens‐Peter Schenk, Jenny Wegert, Manfred Gessler, Leo Kager, Stefan Wagenpfeil, Marina Müller, Jean‐Michel Wolff, Joerg Fuchs, Steven W. Warmann, Clemens‐Magnus Meier, Jochen Hubertus, Christian Rübe, Christian Vokuhl, Patrick Melchior, Lena Tschirner, Norbert Graf, Rhoikos Furtwängler   +17 more
wiley   +1 more source

Mycoplasma - contamination of cell cultures

Биопрепараты: Профилактика, диагностика, лечение, 2018
The safety of biological products derived from animal cells is associated with the properties of the cells themselves or their components, as well as with the possible presence of contaminants of microbial and viral origin.
N. V. Shalunova, R. A. Volkova, A. R. Volgin, E. M. Petruchuk, Z. E. Berdnikova, E. V. Elbert, V. A. Shevtsov, A. V. Rukavishnikov, I. S. Semenova, O. V. Merkulova, G. A. Trusov, N. V. Tereshkina, O. A. Rachinskaj, I. N. Indikova, E. V. Lebedinskaya, E. D. Mytsa   +15 more
doaj  

Analytical Characterization for Similarity Assessment Between an Aflibercept Biosimilar SB15 and Reference Product (Eylea®)

Ophthalmology and Therapy
Introduction SB15 is a proposed biosimilar product of reference aflibercept (Eylea®), an approved biological drug product for retinal diseases including neovascular age-related macular degeneration (nAMD).
Hangyeore Lee, Jongcheol Huh, Dayoung Kim, Soye Lee, Jaeil Lee, Jungmin Lee, Beom Chan Kim, Jinsu Song   +7 more
doaj   +1 more source

Analysis of Global Patenting Trends in Radiopharmaceutical Industry: Diagnostics, Therapy, and Theranostics

Регуляторные исследования и экспертиза лекарственных средств
INTRODUCTION. Radiopharmaceuticals play a crucial role in modern nuclear medicine, offering effective methods for cancer diagnostics, treatment, and theranostics.
M. Yu. Anikeeva, Yu. D. Aleksandrov, Yu. A. Gorbunova, N. V. Popov, A. S. Koshevenko, V. V. Ivashchenko, D. S. Ivanova, E. D. Nikolaeva, A. V. Stepanova, D. I. Fedorova   +9 more
doaj   +1 more source

Pharmacogenetic Approaches to Enhancing Efficacy and Safety of Statins as Illustrated by the Example of Atorvastatin

Безопасность и риск фармакотерапии, 2020
Statins are efficacious lipid-lowering drugs used for prevention of cardiovascular complications in patients with high blood cholesterol. The efficacy and safety of this group of drugs is largely determined by genetic factors. The aim of the study was to
R. Ye. Kazakov, O. A. Checha, I. A. Mazerkina, E. Yu. Demchenkova, T. A. Aleksandrova, V. A. Evteev, S. A. Belkov, A. B. Prokofiev   +7 more
doaj   +1 more source

Inpatient Food Insecurity and Pediatric Hematology Oncology Hospitalization Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Children with cancer and blood disorders are at risk for food insecurity (FI). We aimed to describe the association of inpatient food insecurity (IFI) and hospitalization outcomes among patients admitted to the pediatric hematology oncology service. Of 325 caregivers screened for IFI, 60 (18.6%) screened positive.
Joanna M. Robles, Greg Russell, Leila H. DeWitt, Kimberly Montez, Callie L. Brown   +4 more
wiley   +1 more source

Evaluation of Naked Barley Landraces for Agro-morphological Traits [PDF]

, 2020
Naked barley (Hordeum vulgare var. nudum L.) is a traditional, culturally important, climate-resilient winter cereal crop of Nepal. Evaluation of the naked barely genotypes for yield and disease is fundamental for their efficient utilization in plant ...
Ghimire, K. H. (Krishna), Joshi, B. K. (Bal), Karkee, A. (Ajaya)   +2 more
core  

Characterization for the Similarity Assessment Between the Proposed Biosimilar SB17 and Ustekinumab Reference Product Using State-of-the-Art Analytical Methods

Drugs in R&D
Background SB17 is being developed as a biosimilar to ustekinumab reference product (RP), a human monoclonal antibody (IgG1 kappa immunoglobulin) that binds to the common p40 subunit of cytokines interleukin (IL)-23 and IL-12.
Sung-Yong Yang, Changsoo Lee, Keumbi Hwang, Jungmin Lee, Jaell Lee, Juyong Hong, Seongyoung Jung   +6 more
doaj   +1 more source