FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Development and validation of evaluation indicators for the quality of professional life of Chinese homeroom teachers. [PDF]
Front PsycholSun L, Li A, Li S, Liu Q, Lu J.
europepmc +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Development of nursing quality evaluation indicators for extracorporeal membrane oxygenation based on Donabedian theory: A Delphi study. [PDF]
PLoS OneYu X +5 more
europepmc +1 more source
The RMSM-S+P : a minimal poverty module for the RMSM-X [PDF]
The authors present a new tool, the RMSM-X+P, which essentially consists of a RMSM-X model with an additional module for poverty and social indicators. This linkage facilitates the analysis of the impact of various macroeconomic shocks on a selected set ...
Chen,Derek Hung Chiat +2 more
core
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Evaluation indicators for bladder dysfunction in Chinese patients following cervical cancer surgery: a Delphi study based on nursing outcomes classification. [PDF]
BMC CancerHan X, Di R, Zhang H, Zhou B.
europepmc +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Development of nursing quality evaluation indicators system for pressure injury in orthopedics based on the Donabedian model: a Delphi study. [PDF]
BMC NursZhou L, Hu Y, Shuai P.
europepmc +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source