Results 131 to 140 of about 289,429 (265)
Risk Assessment of a Tunnelling Process Using Machinery Failure Mode and Effects Analysis (MFMEA) [PDF]
In recent years, risk management associated with safety and reliability of the process especially in oil and gas industry has been widely used. For this purpose, different methods of risk analysis have been developed and successfully applied.
جعفری, محمدجواد +1 more
core
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
THE STRATEGIC PERFORMANCE MANAGEMENT PROCESS [PDF]
Contemporary trends in global competition, rapid technological developments and increased use of management information systems and the Internet, developments in planning and control and management thinking, and changing demographics are putting ...
Bagu Constantin +2 more
core
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
АУЫЛ ШАРУАШЫЛЫҒЫ КӘСІПОРЫНДАРЫНДА ДАҒДАРЫСТЫҚ ҚҰБЫЛЫСТАРДЫ АНЫҚТАУ МОДЕЛЬДЕРІН ҚАЛЫПТАСТЫРУ
Экономика: стратегия и практика, 2019 The article deals with the presents and analyzes the key data of need to develop crisis models of agricultural enterprises and crisis management models for the development of agricultural production, which are determined by the risk presence.In ...
doaj
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Strategic principles and capacity building for a whole-of-systems approaches to physical activity [PDF]
, 2020 Allender, Steve +4 more
core
Forest fires: Evaluation of government intervention measures [PDF]
The purpose of this paper is to examine the relation between government measures, volunteer participation, climate variables and forest fires. A number of studies have related forest fires to causes of ignition, to fire history in one area, to the type ...
Clara Riba, Xavier Ballart
core
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source