Results 131 to 140 of about 51,406 (220)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The ESINEA Study: A Novel Screening Tool for Identifying Patient Safety Incidents and Adverse Events in Hospitalized Patients-An Index-Date Cohort Evaluation. [PDF]

Ther Clin Risk Manag
Dueñas Lopez FC, Fernández-Arroyo García A, Rivera Núñez MA, Díaz-Pollán B, Sobrino Jiménez C, Murillo Gayo C, Mendieta Azcona C, Jiménez Núñez C, Yagüe de Antonio G, Narrillos Martín I, Guijarro Eguinoa J, Ojeda Feo JJ, González de la Viuda MA, Bautista Reina MDC, Fernández Velilla Peña M, Jiménez-Gonzalez M, Duque Alcorta M, Álvarez-Montero M, González Muñoz M, Lorente Romeo M, Buitrago Sánchez NM, Rogozina O, López Ortego P, Pardo Puras R, Torres Santos Olmo RM, Iniesta Pérez S, Chajma Izquierdo S, Martín López S, Del Rosal T, Parra Ramírez P, Villán Villán YF, Martín Vega A, Ramírez E.   +32 more
europepmc   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Promoting a social equity approach to sexual harassment prevention across higher education: the Uni4Equity project. [PDF]

Front Public Health
Vives-Cases C, Berbegal-Bernabeu M, Ríos-Albert E, Cerdán-Torregrosa A, Pérez-Martínez V, Jankowiak B, Jaskulska S, Neves S, Sousa M, Topa J, Silva E.   +10 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Adolescents' perceptions of tobacco and electronic cigarette prevention: Six school-based cohorts (2010/11-2023/24). [PDF]

Addict Behav Rep
Rodrigo CS, Escolar-Llamazares MC, Mercado Val EI.   +2 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

A structured framework for the development of knowledge, attitudes, and practices surveys addressing brown dog tick-associated Rocky Mountain spotted fever. [PDF]

Public Health Pract (Oxf)
Romo-Dueñas KP, Enríquez-Ávila DA, Álvarez-Hernández G, De la Torre-Othón SA, Navarro-Armendariz GA, Candia-Plata MC.   +5 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Structuring medication safety narratives: development and evaluation of the medication-related incident reports annotation scheme. [PDF]

Front Digit Health
Alshammari HM, Phipps DL, Le E, Alrdahi H, Lewis PJ, Batista-Navarro R.   +5 more
europepmc   +1 more source