Results 121 to 130 of about 3,745,095 (263)

Towards standardization of economic evaluation research in the youth psychosocial care sector: A broad consultation in the Netherlands. [PDF]

Glob Reg Health Technol Assess, 2020
Evers SMAA, Dirksen CD.
europepmc   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Shanxi province food security evaluation research. [PDF]

Sci Rep
Wang J, Tong M.
europepmc   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Correction: Long COVID clinical evaluation, research and impact on society: a global expert consensus. [PDF]

Ann Clin Microbiol Antimicrob
Ewing AG, Joffe D, Blitshteyn S, Brooks AES, Wist J, Bar-Yam Y, Bilodeau S, Curtin J, Duncan R, Faghy M, Galland L, Pretorius E, Salamon S, Buonsenso D, Hastie C, Kane B, Khan MA, Lal A, Lau D, MacIntyre R, McFarland S, Munblit D, Nicholson J, Ollila HM, Putrino D, Rosario A, Tan T, Long COVID consensus expert panel (Table S1).   +27 more
europepmc   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Editorial: Global excellence in implementation science: Europe

Frontiers in Health Services
Ana Gama, Tayana Soukup, Tayana Soukup, Sónia Dias   +3 more
doaj   +1 more source

Examining Practices Related to Ethical Aspects in eHealth Evaluation Research: Protocol for a Scoping Review. [PDF]

JMIR Res Protoc
Wienands L, Valenta S, Leppla L, De Geest S, Kovács L, Teynor A, Krumme J.   +6 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Long COVID clinical evaluation, research and impact on society: a global expert consensus. [PDF]

Ann Clin Microbiol Antimicrob
Ewing AG, Joffe D, Blitshteyn S, Brooks AES, Wist J, Bar-Yam Y, Bilodeau S, Curtin J, Duncan R, Faghy M, Galland L, Pretorius E, Salamon S, Buonsenso D, Hastie C, Kane B, Khan MA, Lal A, Lau D, MacIntyre R, McFarland S, Munblit D, Nicholson J, Ollila HM, Putrino D, Rosario A, Tan T, Long COVID consensus expert panel (Table S1).   +27 more
europepmc   +1 more source