Heterotropic regulation and negative homotropic cooperativity
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea +5 more
wiley +1 more source
Exploring emotional experience and word-of-mouth mechanisms in male-oriented live-action interactive romance games: a mixed-methods empirical study. [PDF]
QinLi T, Li L.
europepmc +1 more source
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia +9 more
wiley +1 more source
Editorial: AI-powered integrative multi-omics for precision cancer therapies. [PDF]
Tang Q, Xu J, Dao F.
europepmc +1 more source
GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain +11 more
wiley +1 more source
Mapping How Objective Structured Clinical Examinations Are Operationalized to Support Student Learning Across Nursing, Nurse Practitioner, and Medical Education: Protocol for a Scoping Review. [PDF]
Creelman L +4 more
europepmc +1 more source
Editorial: Clinical prediction models in cancer through bioinformatics. [PDF]
Yang W, Wang J, Awasthee N, Singh R.
europepmc +1 more source
Validation in trial-based economic evaluations: a scoping review protocol. [PDF]
Png ME +8 more
europepmc +1 more source

