Results 211 to 220 of about 480,051 (269)

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Bridging Pediatric to Adult Care: A Scoping Review on Transitional Care for Individuals with Congenital Heart Disease Using Data Mining Techniques to Identify Key Topics. [PDF]

Curr Cardiol Rep
Angileri S, Mazzotta R, Ciofi D, Caruso R, Favilli S, Spaziani G, Conte G, Flocco SF, Hendriks JM, Maga G, Perrone PM, Castaldi S, Callus E, Chessa M, Magon A, De Maria M.   +15 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

A double-blind, crossover, non-inferiority randomised controlled trial where primary care providers and patients compare human-generated and AI-generated digital health messages: the AI-CARE study protocol. [PDF]

BMJ Open
Lemieux A, Kutcher SA, Galani Tietcheu BR, Seitz G, Trickovic J, Archibald D, Grosjean S, Hogg W, Johnston S.   +8 more
europepmc   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Evaluation of large language models in cardiovascular surgery: a comparative study of board-level clinical question answering and generation. [PDF]

J Cardiothorac Surg
Yesilkaya MI, Yilmaz U.
europepmc   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

Editorial: Regulatory science: addressing uncertainties in medicines development, evaluation and use. [PDF]

Front Med (Lausanne)
Barbier L, Torre C, Janssens R.
europepmc   +1 more source

Interpreting Echocardiographic Right Ventricular-Pulmonary Arterial Coupling Indices After Transcatheter Tricuspid Intervention. [PDF]

Struct Heart
Pagnoni G, Marangi F, Vicenzi A, Coppi F.   +3 more
europepmc   +1 more source

Management of benign red eye (evaluation of topical oxymetazoline--a double masked study).

Indian journal of ophthalmology, 1986
Vajpayee R, Gupta S, Angra S, Uppal R, Sharma Y, Mehta M   +5 more
openaire   +2 more sources