Results 261 to 270 of about 250,617 (285)

Functional roles and mechanisms of circRNA-protein interactions in cancer progression and tumor immune regulation. [PDF]

Front Immunol
Yang L, Li C, Jiang X, Yuan Y, Li C, Zhou Q, Wang Q, Xiong J.   +7 more
europepmc   +1 more source

Ammonia Detoxification Inhibits Liver Metastasis by Reshaping Hepatic Microenvironment

Advanced Science, EarlyView.
Liver metastasis diverts aspartate into hyperactive pyrimidine synthesis, disrupting urea cycling and causing pathogenic ammonia accumulation. Ammonia dually reprograms the microenvironment by: (1) activating hepatic stellate cells (HSCs) into pro‐fibrotic metastasis‐associated fibroblasts (MAFs), and (2) suppressing anti‐tumor monocytes/macrophages ...
Sumin Sun, Haili Hu, Long Chen, Yuan Gao, Peng Sun, Liming Chen   +5 more
wiley   +1 more source

Reprogramming innate immunity through viral interference: A double-edged strategy for enhancing and containing gene therapies. [PDF]

Mol Ther Nucleic Acids
Liu Z, Song S.
europepmc   +1 more source

Eficiencia y Justicia Fiscal en la Lucha contra la Evasión Tributaria en Ecuador, Optimizar el proceso de enseñanza-aprendizaje de estudiantes aplicando herramientas informáticas, Comparado entre Países en Desarrollo y Desarrollados

Wilmer Olmedo Espinoza Toalombo, Omar Rodrigo Montece Moreno, Lía Margarita De Mora Campi   +2 more
openalex   +1 more source

Dual‐Targeting Cuproptosis and Mitophagy via a Flavopiridol‐Copper Nanoplatform Potentiates Immunotherapy Against Uveal Melanoma

Advanced Science, EarlyView.
This study develops a GSH‐responsive nanoplatform, NP@Fla‐Cu, to co‐activate cuproptosis and excessive mitophagy in uveal melanoma. The nanoplatform enhances tumor‐specific copper delivery, depletes antioxidant defenses, and remodels the tumor immune microenvironment.
Hong Ren, Zhihong Deng, Sheng Lu, Jing Zhang, Wenbin Liu, Jia Tan   +5 more
wiley   +1 more source

Immune dysregulation in <i>Mycoplasma pneumoniae</i> pneumonia: mechanistic controversies and clinical translation from inflammatory dysregulation and immune evasion to chronic injury. [PDF]

Front Immunol
Li X, Wang Y, Wang Q, Wu H, Yan Y, Xiong Y, Ding Y.   +6 more
europepmc   +1 more source

Bioprinted Tumor Microenvironment Models Reveal Immune Evasion and Guide CAR‐NK Therapeutic Strategies

Advanced Science, EarlyView.
This study presents a 3D embedded bioprinting platform that recapitulates key stromal features of the tumor microenvironment using fibroblasts and lung‐derived ECM. The model enables functional assessment of CAR‐NK cells and provides a versatile tool to support the development of next‐generation immunotherapeutic strategies against solid tumors ...
Dahong Kim, Seona Jo, In‐Hwan Jang, Yu‐Jin Kim, Youngmee Jung, Junhyoung Ahn, Hyungjun Lim, Jae Jong Lee, Kangwon Lee, Tae‐Don Kim, Su A Park   +10 more
wiley   +1 more source

Porcine hemagglutinating encephalomyelitis virus nucleocapsid protein targets RIG-I and IRF3 to evade IFN immunity. [PDF]

J Virol
Mu S, Bai Y, Qiu R, Zhang F, Shi J, Lan Y, Gao F, He W, Li Z.   +8 more
europepmc   +1 more source

Advances in Metabolic Reprogramming and Immune Regulatory Mechanisms in Lung Cancer. [PDF]

Oncol Res
Li X, Li X, Wu H, Li R.
europepmc   +1 more source

ADAMDEC1-driven CCL2-CCR2-PD-1 axis in esophageal squamous cell carcinoma: a dual threat of O-GlcNAcylation and m⁶A methylation in neoadjuvant therapy resistance and immune evasion. [PDF]

Cell Oncol (Dordr)
Cheng J, Ma H, Qian X, Xing W.
europepmc   +1 more source