Results 191 to 200 of about 1,173,800 (295)

The Immunoregulatory and Hematopoietic Effects of Momelotinib in a Murine Bone Marrow Failure Model

Journal of Clinical Laboratory Analysis, EarlyView.
Momelotinib, a selective small‐molecule inhibitor of JAK1/2 and the bone morphogenic protein receptor kinase activin A receptor type I (ACVR1), exerts its effects by inhibiting the overactivation of the BMP/ACVR1/SMAD signaling pathway. This inhibition reduces hepcidin production in hepatocytes, and reduces inflammation, aberrant cytokine signaling ...
Yue Zhang, Huiqin Zhang, Naibo Hu, Liping Yang, Yumei Liu, Liyan Yang, Xifeng Dong, Huaquan Wang   +7 more
wiley   +1 more source

Pathogen Evasion of Humoral Innate Immunity: Coping with C-Reactive Protein and Serum Amyloid A. [PDF]

Int J Mol Sci
Gong W, Cheng X, Villena J, Kitazawa H.
europepmc   +1 more source

The Individual and Combined Effects of Warming and Atrazine on Lithobates pipiens Phenotypes: Implications for Frog Declines

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
ABSTRACT Amphibians are the most threatened vertebrate class globally. Climate change, agrochemicals, and/or pathogens and parasites are implicated in contributing to amphibian declines, either singly or in combination. We investigated individual and combined effects of elevated temperatures and atrazine (2.0 μg/L) on Lithobates [formerly Rana] pipiens
Melody J. Gavel, Mark R. Forbes, Derek D. N. Smith, Julia Darabaner, Yol Monica Reyes, Zintis Stasko, David J. Carpenter, Stacey A. Robinson   +7 more
wiley   +1 more source

Behavioural response of prey to repeated attacks by non-coordinating predators. [PDF]

Sci Rep
Mohapatra S, Sinha Mahapatra P.
europepmc   +1 more source

Tumor aneuploidy correlates with markers of immune evasion and with reduced response to immunotherapy

Science, 2017
T. Davoli, H. Uno, Eric C. Wooten, S. Elledge   +3 more
semanticscholar   +1 more source

Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley   +1 more source

Getting into host's skin: initial immune response to <i>Schistosoma mansoni</i> infection. [PDF]

Front Immunol
Orrico-Ferreira CM, Cruz PEO, Rios JVB, da Silva Rosa W, Santos BS, Silva RC, Pinheiro CS, Figueiredo BC.   +7 more
europepmc   +1 more source

Paraneoplastic Florid Oral Papillomatosis and Malignant Acanthosis Nigricans Associated With HPV‐Related Squamous Cell Carcinoma of Unknown Primary

JEADV Clinical Practice, EarlyView.
ABSTRACT We present the case of a 76‐year‐old man with paraneoplastic florid oral papillomatosis (FOP) and malignant acanthosis nigricans (MAN) associated with an HPV‐16‐positive keratinizing squamous cell carcinoma of unknown primary. The patient initially presented with a painless left cervical mass and was diagnosed through cytology and PET‐CT ...
Jose Ángel Amat‐Sanchez, Ander Paulo Mayor‐Ibarguren, María José Beato‐Merino, Blanca Martínez‐Cabrera, Beatriz Castelo‐Fernández, Francisco Vergara‐Barria, Pedro Herranz‐Pinto   +6 more
wiley   +1 more source

Proteomics of Nitrotyrosine: Integrating Mass Spectrometry and Immunodetection in Redox‐Driven Pathology

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Nitrooxidative stress, driven by excess reactive nitrogen species like peroxynitrite, contributes to the pathogenesis of many chronic diseases. Among its molecular footprints, 3‐nitrotyrosine (3NT) has emerged as a biologically relevant marker of protein nitration.
Brîndușa Alina Petre
wiley   +1 more source

PRSS22 promotes the immune evasion of gastric cancer via inhibiting ANXA1-mediated degradation of PD-1. [PDF]

Food Nutr Res
Wang J, Zhou J, Chen X.
europepmc   +1 more source