Results 111 to 120 of about 587,928 (338)

Lipid metabolism in pancreatic cancer: emerging roles and potential targets

Cancer Communications, Volume 42, Issue 12, Page 1234-1256, December 2022., 2022
Abstract Pancreatic cancer is one of the most serious health issues in developed and developing countries, with a 5‐year overall survival rate currently <9%. Patients typically present with advanced disease due to vague symptoms or lack of screening for early cancer detection.
Xinpeng Yin, Ruiyuan Xu, Jianlu Song, Rexiati Ruze, Yuan Chen, Chengcheng Wang, Qiang Xu   +6 more
wiley   +1 more source

Controlling tax evasion fluctuations [PDF]

arXiv, 2008
We incorporate the behaviour of tax evasion into the standard two-dimensional Ising model and augment it by providing policy-makers with the opportunity to curb tax evasion via an appropriate enforcement mechanism. We discuss different network structures in which tax evasion may vary greatly over time if no measures of control are taken.
arxiv  

TRIM38 Suppresses the Progression of Colorectal Cancer via Enhancing CCT6A Ubiquitination to Inhibit the MYC Pathway

Advanced Science, EarlyView.
This study reveals the tumor‐suppressive role of TRIM38 in colorectal cancer (CRC). TRIM38 is downregulated through DNA hypermethylation and correlates with unfavorable clinical features and poor prognosis. Mechanistically, TRIM38 inhibits CRC progression by promoting K48‐linked ubiquitination of CCT6A, leading to the destabilization of c‐Myc.
Yue Zhang, Xinyu Tan, Lu Wang, Dongjian Ji, Chuan Zhang, Wen Peng, Renzhong Zhu, Xiaowei Wang, Jiahui Zhou, Yifei Feng, Yueming Sun   +10 more
wiley   +1 more source

Integrative Multi‐Omics and Routine Blood Analysis Using Deep Learning: Cost‐Effective Early Prediction of Chronic Disease Risks

Advanced Science, EarlyView.
Omicsformer, a deep learning model, integrates multi‐omics and routine blood data to accurately predict risks for nine chronic diseases, including cancer and cardiovascular conditions. Validated using large scale clinical data, it reveals early risk trajectories, advancing personalized medicine and offering a cost‐effective, community‐based solution ...
Zhibin Dong, Pei Li, Yi Jiang, Zhihan Wang, Shihui Fu, Hebin Che, Meng Liu, Xiaojing Zhao, Chunlei Liu, Chenghui Zhao, Qin Zhong, Chongyou Rao, Siwei Wang, Suyuan Liu, Dayu Hu, Dongjin Wang, Juntao Gao, Kai Guo, Xinwang Liu, En Zhu, Kunlun He   +20 more
wiley   +1 more source

Analyzing the Role of Blockchain in Realizing Islamic Banking with a Perspective on the Constitution of the Islamic Republic of Iran [PDF]

پژوهش‌نامه حقوق اسلامی
‌ ∴ Introduction ∴ ‌The concept of Islamic banking is grounded in principles that emphasize rights, justice, and public welfare, aiming to manifest human ethics in financial transactions.
Kheirollah Parvin, Vali Rostami, Nader Mirzadeh Koohshahi, Ali Allahyarifard   +3 more
doaj   +1 more source

Dissecting the Spatial and Single‐Cell Transcriptomic Architecture of Cancer Stem Cell Niche Driving Tumor Progression in Gastric Cancer

Advanced Science, EarlyView.
A single‐cell and spatial transcriptional atlas reveals the architecture of human gastric cancer stem cell (CSC) niche and the developmental trajectory of CSCs. These CSCs interact with immunosuppressive immune cells thereby constructing immune‐suppressive niche, and inflammatory cancer‐associated fibroblast (iCAFs) to enhance stemness through ...
Guangyu Zhang, Xin Zhang, Wenting Pan, Xizhao Chen, Lingfei Wan, Chunjie Liu, Yuting Yong, Yue Zhao, Shuli Sang, Lihua Zhang, Sheng Yao, Yushu Guo, Mingmei Wang, Xinhui Wang, Guangdun Peng, Xinlong Yan, Yanchun Wang, Min Zhang   +17 more
wiley   +1 more source

Notary/PPAT Responsibility for Misuse of Tax Fund Custody by Parties

International Journal of Islamic Education, Research and Multiculturalism
In recent decades, many notaries/PPATs have been involved in legal issues, both intentionally and unintentionally. One problem that often occurs is the abuse of trust related to land rights tax payments entrusted by service users to notaries/PPATs ...
Putri Hijrotul Lutfiah, Dewi Cahyandari, Imam Rahmat Sjafi'i   +2 more
doaj   +1 more source

Verteporfin‐Mediated In Situ Nanovaccine Based on Local Conventional‐Dose Hypofractionated Radiotherapy Enhances Antitumor and Immunomodulatory Effect

Advanced Science, EarlyView.
Here gelatinase‐responsive methoxypolyethyleneglycol–PVGLIG–polycaprolactone (mPEG–PVGLIG–PCL) nanoparticles’ loading verteporfin (N@VP) is developed, enhancing radiotherapy via X‐ray‐triggered singlet oxygen generation. Combined with 2 Gy (gray, a radiation dose unit) irradiation, N@VP achieves antitumor efficacy comparable to 8 Gy, and also promotes ...
Zhifan Zhang, Lin Li, Yuchen Ge, Anni Chen, Shanchao Diao, Yueling Yang, Qianyue Chen, Yingling Zhou, Jie Shao, Fanyan Meng, Lixia Yu, Manman Tian, Xiaoping Qian, Zhaoyu Lin, Chen Xie, Baorui Liu, Rutian Li   +16 more
wiley   +1 more source

Preventing Jailbreak Prompts as Malicious Tools for Cybercriminals: A Cyber Defense Perspective [PDF]

arXiv
Jailbreak prompts pose a significant threat in AI and cybersecurity, as they are crafted to bypass ethical safeguards in large language models, potentially enabling misuse by cybercriminals. This paper analyzes jailbreak prompts from a cyber defense perspective, exploring techniques like prompt injection and context manipulation that allow harmful ...
arxiv  

Making ethical decisions for the immersive web [PDF]

arXiv, 2019
Mixed reality (MR) ethics occupies a space that intersects with web ethics, emerging tech ethics, healthcare ethics and product ethics (among others). This paper focuses on how we can build an immersive web that encourages ethical development and usage.
arxiv