Results 121 to 130 of about 587,928 (338)

Tumor Microenvironment On‐A‐Chip and Single‐Cell Analysis Reveal Synergistic Stromal–Immune Crosstalk on Breast Cancer Progression

open access: yesAdvanced Science, EarlyView.
Using a 3D tumor microenvironment (TME)‐on‐a‐chip model, tumor–stromal–immune crosstalk in triple‐negative breast cancer is studied, revealing the TME's combinatorial effect on cancer progression. Integrating single‐cell transcriptomic analysis demonstrates metabolic reprogramming via the kynurenine pathway, highlighting the complex TME cellular ...
Kalpana Ravi   +7 more
wiley   +1 more source

DIESEL -- Dynamic Inference-Guidance via Evasion of Semantic Embeddings in LLMs [PDF]

open access: yesarXiv
In recent years, large language models (LLMs) have had great success in tasks such as casual conversation, contributing to significant advancements in domains like virtual assistance. However, they often generate responses that are not aligned with human values (e.g., ethical standards, safety), leading to potentially unsafe or inappropriate outputs ...
arxiv  

Single‐Cell Atlas Reveals Tumorigenic Profiles and Immune Dynamics of Adrenal Incidentalomas

open access: yesAdvanced Science, EarlyView.
Single‐cell RNA sequencing reveals cellular heterogeneity in adrenal incidentalomas, identifying distinct tumor cell populations. Clusterin is recognized as a biomarker for adrenocortical tumors, correlating with established markers. MYCN‐positive clusters in pheochromocytomas indicated poorer survival.
Meng Wang   +18 more
wiley   +1 more source

A CLDN18.2‐Targeted Nanoplatform Manipulates Magnetic Hyperthermia Spatiotemporally for Synergistic Immunotherapy in Gastric Cancer

open access: yesAdvanced Science, EarlyView.
CLDN18.2 is a highly selective biomarker exposed in gastric cancer. A CLDN18.2‐specific antibody 1D5 conjugated fluorescence‐magnetic nanoparticle is developed for image‐guided precision theragnostics. Under the assistance of sensitive FMI and deep‐penetrating MPI for tracing and timing the optimal nanoparticle dosage, combining α‐PD1 therapy with ...
Xueying Wang   +14 more
wiley   +1 more source

The Evasiveness Conjecture and Graphs on 2p Vertices [PDF]

open access: yesarXiv, 2016
The Evasiveness conjecture have been proved for properties of graphs on a prime-power number of vertices and the six vertices case. The ten vertices case is still unsolved. In this paper we study the size of the automorphism group of a graph on $2p$ vertices to estimate the Euler characteristic of monotone non-evasive graph properties and get some ...
arxiv  

Reprogramming the Tumor Immune Microenvironment with ICAM‐1‐Targeted Antibody‒Drug Conjugates and B7‐H3‐CD3 Bispecific Antibodies

open access: yesAdvanced Science, EarlyView.
Reprogramming the tumor immune microenvironment is crucial for transforming immune “cold” tumors into “hot” inflammatory tumors. The investigation reveals that the combination of ICAM‐1‐Dxd with B7‐H3‐CD3 bispecific antibodies not only demonstrates significant inhibitory effects on tumor growth and metastasis but also plays a vital role in ...
Shoubing Zhou   +9 more
wiley   +1 more source

Tax Compliance Pattern Analysis: A Survey-Based Approach

open access: yesInternational Journal of Financial Studies
This study investigates tax compliance patterns among individuals in Romania through a survey-based approach, aiming to comprehend factors influencing taxpayers’ behavior, including perception towards taxation, ethics, evasion, and public awareness.
Marius-Răzvan Surugiu   +5 more
doaj   +1 more source

Is ETHICS about ethics? Evaluating the ETHICS benchmark [PDF]

open access: yesarXiv
ETHICS is probably the most-cited dataset for testing the ethical capabilities of language models. Drawing on moral theory, psychology, and prompt evaluation, we interrogate the validity of the ETHICS benchmark. Adding to prior work, our findings suggest that having a clear understanding of ethics and how it relates to empirical phenomena is key to the
arxiv  

A Novel Theranostic Strategy for Malignant Pulmonary Nodules by Targeted CECAM6 with 89Zr/131I‐Labeled Tinurilimab

open access: yesAdvanced Science, EarlyView.
This study investigates the integrated diagnostic and therapeutic strategy utilizing 89Zr/131I‐labeled tinurilimab for the management of malignant lung nodules, with a particular focus on lung adenocarcinoma (LUAD). CEACAM6, which is highly expressed in most LUAD patients, activates the Src/FAK signaling pathway, thereby promoting cell proliferation ...
Chongyang Chen   +8 more
wiley   +1 more source

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