Results 141 to 150 of about 587,928 (338)

Towards a research ethics of real-world experimentation with emerging technology

Journal of Responsible Technology
Testing emerging technologies, such as autonomous vehicles, predictive crime analytics, and smart city interventions under real-world conditions is an important strategy for robust and responsible technology development.
Joost Mollen
doaj  

Unveiling Large Language Models Generated Texts: A Multi-Level Fine-Grained Detection Framework [PDF]

arXiv
Large language models (LLMs) have transformed human writing by enhancing grammar correction, content expansion, and stylistic refinement. However, their widespread use raises concerns about authorship, originality, and ethics, even potentially threatening scholarly integrity.
arxiv  

Mechanical Biomimetic Nanocomposites for Multidimensional Treatment of Arterial Thrombosis

Advanced Science, EarlyView.
In this study, a mechanical biomimetic nanocomposite is developed, guided by photoacoustic imaging, to achieve highly efficient and safe thrombolysis through the synergistic effects of photothermal therapy and pharmacological intervention. Most notably, the nanoparticle improves the microenvironment of arterial thrombi, marked by high shear stress and ...
Ying Li, Qi Xiang, Yan Zhang, Fuxue Luo, Yunfang Wu, Haitao Ran, Yang Cao   +6 more
wiley   +1 more source

Vascular co‐option and vasculogenic mimicry mediate resistance to antiangiogenic strategies

Cancer Reports, Volume 5, Issue 12, December 2022., 2022
Abstract Background The concept that all the tumors need the formation of new vessels to grow inspired the hypothesis that inhibition of angiogenesis would have led to “cure” cancer. The expectancy that this type of therapy would have avoided the insurgence of resistance was based on the concept that targeting normal vessels, instead of the cancer ...
Francesco Pezzella, Domenico Ribatti
wiley   +1 more source

SACA: A Scenario-Aware Collision Avoidance Framework for Autonomous Vehicles Integrating LLMs-Driven Reasoning [PDF]

arXiv
Reliable collision avoidance under extreme situations remains a critical challenge for autonomous vehicles. While large language models (LLMs) offer promising reasoning capabilities, their application in safety-critical evasive maneuvers is limited by latency and robustness issues.
arxiv  

Bacterial Capture‐Killing Capsules with Remodeling Bone Immune Microenvironment for the Effective Treatment of Osteomyelitis

Advanced Science, EarlyView.
The PC‐O@TOB capsules are designed to exhibit bactericidal effects, regulate the bone immune microenvironment by promoting M2 macrophage polarization, eliminate excessive ROS, and enhance bone regeneration, providing a novel multi‐dimensional approach for the treatment of osteomyelitis.
Dong Yang, Chang Shu, Chengwei Xu, Xingjie Zan, Shaoyin Wei, Chenglong Wang, Lianxin Li   +6 more
wiley   +1 more source

Targeting radiation‐induced upstream stimulatory factor‐1 by histone deacetylase inhibitors to reverse radioresistance in prostate cancer

Cancer Reports, Volume 5, Issue 12, December 2022., 2022
Abstract Background Ionizing radiation (IR) is a standard modality for the management of solid tumors. Apart from its killing effects, IR can induce pro‐survival factors leading to radioresistance of cancer. Mechanistic understanding of radiation resistance is warranted to overcome the pro‐survival effects of IR.
Seema Gupta, Mansoor M. Ahmed
wiley   +1 more source

Methionine Metabolism Dictates PCSK9 Expression and Antitumor Potency of PD‐1 Blockade in MSS Colorectal Cancer

Advanced Science, EarlyView.
xxxx. Abstract Nutrient metabolisms are vitally interrelated to cancer progression and immunotherapy. However, the mechanisms by which nutrient metabolisms interact to remodel immune surveillance within the tumor microenvironment remain largely unexplored.
Qi‐Long Wang, Zijie Chen, Xiaofei Lu, Huizhen Lin, Huolun Feng, Nuozhou Weng, Liwen Chen, Mengnan Liu, Li Long, Lingjun Huang, Yongmei Deng, Kehong Zheng, Xiaojun Zheng, Yong Li, Ting Cai, Jiabin Zheng, Wei Yang   +16 more
wiley   +1 more source

A Smart Single‐Loop‐Mediated Isothermal Amplification Facilitates Flexible SNP Probe Design for On‐Site Rapid Differentiation of SARS‐CoV‐2 Omicron Variants

Advanced Science, EarlyView.
The ssLAMP method amplifies the nucleic acid of pathogen and identifies SNP mutations. By combining the portable detection device with smartphone‐based analysis software, enables rapid, on‐site SNP detection and genotyping of SARS‐Cov‐2 Omicron variants, providing a cost‐effective and field‐deployable solution for precise pathogen identification in ...
Qijie Lin, Hongchao Gou, Xiaoyun Qu, Kaiyuan Jia, Yuhui Deng, Dan Li, Qianyi Cai, Yucen Liang, Xiaozhen Xu, Yanbin Li, Jianhan Lin, Letian Li, Yuhang Jiang, Shouwen Du, Lingcong Deng, Bailing Yan, Ruidong Liu, Chang Li, Jianmin Zhang, Ming Liao   +19 more
wiley   +1 more source

FP-Inconsistent: Detecting Evasive Bots using Browser Fingerprint Inconsistencies [PDF]

arXiv
As browser fingerprinting is increasingly being used for bot detection, bots have started altering their fingerprints for evasion. We conduct the first large-scale evaluation of evasive bots to investigate whether and how altering fingerprints helps bots evade detection.
arxiv