Results 171 to 180 of about 595,294 (317)

The DCDC2/ENO1 axis promotes tumor progression and immune evasion in intrahepatic cholangiocarcinoma via activating FGL1-LAG3 checkpoint. [PDF]

J Exp Clin Cancer Res
Wan W, Li Y, Sun W, Cheng Z, Ma F, Shen S, Liu H, Zhang J.   +7 more
europepmc   +1 more source

Enhancing Chemotherapy‐Related Immune Responses via Bioorthogonal Metabolic Engineering‐Driven Tumor Exosomes Elimination

Advanced Science, EarlyView.
In this work, a novel strategy named bioorthogonal reaction‐driven exosome elimination (Biordee) strategy was developed to inhibit chemotherapy‐associated breast cancer metastasis and enhance the immune response. Biordee possessed the capacity of in‐situ editing tumor‐derived exosomes (TExo) with IgG Fc and promoted macrophage phagocytosis of ...
Wentao Zhang, Tianyi Yang, Tian Jin, Tianyi Zhu, Fang Hao, Miao Fan, Yanrong Zhang   +6 more
wiley   +1 more source

The impact of vascular endothelial growth factor on oral squamous cell carcinoma through dendritic cell induction and facilitation of tumor immune tolerance. [PDF]

Discov Oncol
Zhang P, Xu Y, Cai B, Xu J, Wang T, Xu H.   +5 more
europepmc   +1 more source

ROS‐Responsive Hydrogel for Localized Delivery of Nampt and Stat3 Inhibitors Exhibits Synergistic Antitumor Effects in Colorectal Cancer Through Ferroptosis Induction and Immune Microenvironment Remodeling

Advanced Science, EarlyView.
In this study, ferroptosis in colorectal cancer cells is induced by FK866 through the NAD⁺/STAT3/GPX4 pathway. To minimize systemic toxicity, a reactive oxygen species (ROS)‐responsive hydrogel is developed to co‐deliver FK866 and C188‐9, resulting in synergistic and localized antitumor effects.
Chenyang Ye, Mi Mi, Saimeng Shi, Lina Qi, Shanshan Weng, Lu Wang, Yier Lu, Chao Chen, Yinuo Tan, Mengyuan Yang, Cheng Guo, Rui Bai, Xuefeng Fang, Ji Wang, Ying Yuan   +14 more
wiley   +1 more source

PRMT1 promotes immune escape in hepatocellular carcinoma by regulating arginine methylation modification of MYC protein. [PDF]

Epigenetics
Zhou H, Wang Y, Wang D, Zhang M, Wang K, Liu C.   +5 more
europepmc   +1 more source

RUNX1/SLAMF3 Axis Drives Immunosuppression to Contribute to Colorectal Cancer Liver Metastasis by Blocking Phagocytosis and Depleting C1QC+ Tumor‐Associated Macrophages

Advanced Science, EarlyView.
This study identifies the RUNX1/SLAMF3 axis as a key driver of colorectal cancer liver metastasis (CRLM). SLAMF3 suppresses macrophage phagocytosis and depletes C1QC⁺ tumor‐associated macrophages, promoting an immunosuppressive microenvironment. Targeting this axis restores macrophage and CD8⁺ T cell activity and reduces metastasis.
Yinheng Luo, Xiaoli Jin, Lan Huang, Dejia Zeng, Nan Zhang, Shiyu Tang, Shu Luo, Samina Ejaz Syed, Ruiwu Dai, Qiu Li, Shufang Liang   +10 more
wiley   +1 more source

Unmet psychological needs underlying mobile phone dependence among medical undergraduates: a qualitative study based on the basic psychological needs theory. [PDF]

Front Psychol
Chen J, Guo Y, Huang R, Liu G, Zhang B.
europepmc   +1 more source

A Novel Class of Multi‐substituted Diaryl Scaffold Derivatives Inhibit Glioblastoma Progression by Targeting CD155

Advanced Science, EarlyView.
Structural modification of clofoctol yielded a novel blood‐brain barrier‐permeable compound, B7, featuring a multi‐substituted diaryl scaffold. B7 demonstrates potent anti‐glioblastoma activity by suppressing glioblastoma stem cells proliferation, migration, and invasion through interactions with five key residues of poliovirus receptor cell adhesion ...
Yong‐jian Wang, Ting Sun, Si‐tu Xue, Zhong‐di Cai, Hong Yi, Miao Lv, Shi‐bo Kou, Rui Liu, Xiao‐zhong Peng, Zhuo‐rong Li   +9 more
wiley   +1 more source

Whole genome sequencing reveals virulence-mobile element linkages and phylogenetic diversity in multidrug-resistant <i>Escherichia coli</i> from Nigeria. [PDF]

Front Microbiol
Medugu N, Aworh MK, Iregbu K, Nwajiobi-Princewill P, Hull DM, Harden L, Singh P, Obaro S, Egwuenu A, Adeboye F, Egah R, Uzairue L, Mohammed Y, Ifeyinwa N, Thakur S.   +14 more
europepmc   +1 more source

EGFR‐TKIs Induced DPP4 Drives Metabolic Reprogramming of Persister Cells in Lung Cancer

Advanced Science, EarlyView.
Drug‐tolerant persister (DTP) cells emerge early during EGFR‐TKI treatment, preceding the development of acquired resistance. Elevated DPP4 in DTP cells drives metabolic reprogramming and antioxidant adaptation, promoting cell survival under drug pressure.
Yuanzhou Zhang, Xiaojun Zhang, Xupeng Yang, Xingshi Chen, Yuehong Wang, Jingying Hu, Rui Liu, Xiaoying Luo   +7 more
wiley   +1 more source