Results 181 to 190 of about 587,928 (338)

The peritumoral brain zone in glioblastoma: where we are and where we are going

Journal of Neuroscience Research, Volume 101, Issue 2, Page 199-216, February 2023., 2023
Abstract Glioblastoma (GBM) is the most aggressive and invasive primary brain tumor. Current therapies are not curative, and patients' outcomes remain poor with an overall survival of 20.9 months after surgery. The typical growing pattern of GBM develops by infiltrating the surrounding apparent normal brain tissue within which the recurrence is ...
Martina Giambra, Andrea Di Cristofori, Silvia Valtorta, Roberto Manfrellotti, Vittorio Bigiogera, Gianpaolo Basso, Rosa Maria Moresco, Carlo Giussani, Angela Bentivegna   +8 more
wiley   +1 more source

PCBP2 promotes immune evasion via cGAS-STING pathway in biochemical recurrence of prostate cancer. [PDF]

APL Bioeng
Zhou Z, Li T, Zhang Y, Zhou X, Song X, Ji S, Huang Y, Zhang Y, Ruan Y.   +8 more
europepmc   +1 more source

Cuproplasia and cuproptosis, two sides of the coin

Cancer Communications, EarlyView.
Abstract Copper is an essential micronutrient in the human body, mainly acting as a crucial cofactor required for a wide range of physiological processes across nearly all cell types. Recent advances revealed that tumor cells seize copper to fulfill their rapid proliferation, metastasis, immune evasion, and so on by reprogramming the copper regulatory ...
Kaizhong Lu, Chandra Sugiarto Wijaya, Qinghua Yao, Hongchuan Jin, Lifeng Feng   +4 more
wiley   +1 more source

PD-1 suppression enhances HIV reactivation and T-cell immunity via MAPK/NF-κB signaling. [PDF]

Eur J Med Res
Lin X, Song B, Cao L, Zhang L, Liu S, Wang X, Chen X, Li S.   +7 more
europepmc   +1 more source

Breaking barriers: Smart vaccine platforms for cancer immunomodulation

Cancer Communications, EarlyView.
Abstract Despite significant advancements in cancer treatment, current therapies often fail to completely eradicate malignant cells. This shortfall underscores the urgent need to explore alternative approaches such as cancer vaccines. Leveraging the immune system's natural ability to target and kill cancer cells holds great therapeutic potential ...
Mohammad Mahmoudi Gomari, Taha Ghantabpour, Nima Pourgholam, Neda Rostami, Stephen M. Hatfield, Farzaneh Namazifar, Shadi Abkhiz, Seyed Sadegh Eslami, Mahsa Ramezanpour, Mahsa Darestanifarahani, Igor Astsaturov, Sidi A. Bencherif    +11 more
wiley   +1 more source

BMI1 induces ubiquitination and protein degradation of Nod‐like receptor family CARD domain containing 5 and suppresses human leukocyte antigen class I expression to induce immune escape in non‐small cell lung cancer

The Kaohsiung Journal of Medical Sciences, Volume 38, Issue 12, Page 1190-1202, December 2022., 2022
Abstract The Nod‐like receptor (NLR) family CARD domain containing 5 (NLRC5) has been reported as an activator of human leukocyte antigen (HLA) class I that is responsible for immune activity in cancer treatment. This work focuses on the role of BMI1 proto‐oncogene (BMI1) in the NLRC5‐HLA class I axis and in immune escape in non‐small cell lung cancer (
Zhi‐Hui Lu, Gan‐Jie Tu, Si‐Lv Fu, Kai Shang, Su‐Juan Peng, Li Chen, Xi‐Juan Gu   +6 more
wiley   +1 more source

Integrated analysis reveals an immune evasion prognostic signature for predicting the overall survival in patients with hepatocellular carcinoma. [PDF]

Cancer Cell Int
Wen J, Wen K, Tao M, Zhou Z, He X, Wang W, Huang Z, Lin Q, Li H, Liu H, Yan Y, Xiao Z.   +11 more
europepmc   +1 more source

Pan‐cancer analysis shapes the understanding of cancer biology and medicine

Cancer Communications, EarlyView.
Abstract Advances in multi‐omics datasets and analytical methods have revolutionized cancer research, offering a comprehensive, pan‐cancer perspective. Pan‐cancer studies identify shared mechanisms and unique traits across different cancer types, which are reshaping diagnostic and treatment strategies.
Xiaoping Cen, Yuanyuan Lan, Jiansheng Zou, Ruilin Chen, Can Hu, Yahan Tong, Chen Zhang, Jingyue Chen, Yuanmei Wang, Run Zhou, Weiwei He, Tianyu Lu, Fred Dubee, Dragomirka Jovic, Wei Dong, Qingqing Gao, Man Ma, Youyong Lu, Yu Xue, Xiangdong Cheng, Yixue Li, Huanming Yang   +21 more
wiley   +1 more source

Exposure of monocyte-derived macrophages to the UV-inactivated SARS-CoV-2 VOCs shows similar effects on the transcriptomic profile as active virus: a comparative analysis. [PDF]

J Transl Med
Sammartino JC, Vazzana R, Cuscino N, Castelbuono S, Giambruno R, Carcione C, Miceli V, Bulati M, Lilleri D, Conaldi PG, Baldanti F, Gallo A, Cassaniti I.   +12 more
europepmc   +1 more source

Attitudes on the ethics of tax evasion : a brazilian survey

, 2020
The main objective of this dissertation is to assess the attitudes of Brazilians towards the ethics of tax evasion and on a second level to analyze the influence of several socio-demographic variables on tax ethics. The study of tax ethics in Brazil is relevant, given the numerous cases involving corruption and tax evasion, such as the Operação Lava ...
openaire   +1 more source