Results 181 to 190 of about 595,294 (317)

A Nano‐Electro‐Platform Enabling Evolutionary Screening and Remodeling of Tumor Cells for Metastasis Inhibition

open access: yesAdvanced Science, EarlyView.
The nano‐electro‐platform achieves non‐destructive evolutionary screening and electro‐remodeling of tumor cells to generate extracellular vesicles with enhanced tumor‐targeting and therapeutic functions. These extracellular vesicles demonstrate remarkable efficacy in activating both macrophages and T cells, thereby orchestrating a potent immune ...
Feng Liu   +20 more
wiley   +1 more source

Nature‐Inspired Nanostructures from Multiple‐Species Biomembranes: Rational Engineering and Therapeutic Applications in Tumor‐Targeted Nanomedicine

open access: yesAdvanced Science, EarlyView.
Naturally derived biomembrane nanostructures by mimicking evolutionarily optimized biological architectures could effectively suppress tumor growth and have emerged as a compelling strategy in translational biomedicine. This review provides a systematic overview of rational design and underlying antitumor therapeutic mechanisms of mammalian cells ...
Xiaodan Wei   +10 more
wiley   +1 more source

Personalized Neoantigen Vaccine plus Regorafenib Increases Rgs2⁺CD8⁺ T Cells Infiltration and Reprograms the Tumor Microenvironment in Microsatellite Stable Colorectal Cancer Liver Metastases

open access: yesAdvanced Science, EarlyView.
This study synthesized a personalized neoantigen vaccine (Neo‐CRCVAS) and combined it with regorafenib, termed RegoNeo. This combination therapy significantly enhanced antitumor efficacy and promoted long‐term tumor‐specific immune memory in microsatellite stable colorectal cancer liver metastasis (MSS‐CRLM) models by increasing neoantigen‐specific ...
Hengkai Chen   +11 more
wiley   +1 more source

Postoperative Prognostic Nutritional Index as a Useful Prognostic Factor in Patients With Gastric Cancer

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
In patients after gastric cancer surgery, low postoperative PNI values, considering nutritional status, surgical stress, and postoperative inflammatory response, were significantly associated with poor prognosis in terms of both RFS and OS. ABSTRACT Aim To verify whether postoperative prognostic nutritional index is a useful prognostic factor in ...
Masaaki Yamamoto   +9 more
wiley   +1 more source

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