Results 251 to 260 of about 656,094 (362)

Identification of an immunomodulatory lncRNA signature associated with immune cell reprogramming in high-grade glioma. [PDF]

Cancer Gene Ther
Canella A, Rajappa P.
europepmc   +1 more source

Lactate Dehydrogenase C4 Accelerates Triple‐Negative Breast Cancer Progression by Promoting Acetyl‐CoA Acyltransferase 2 Lactylation to Increase Free Fatty Acid Accumulation

Advanced Science, EarlyView.
Diagram of the reprogramming of FA metabolism mediated by LDHC4‐induced ACAA2 activity to promote TNBC progression. LDHC4 drives TNBC progression by enhancing ACAA2‐mediated fatty acid production. The resulting accumulation of FFAs stimulates autophagy and accelerates cell cycle progression, thereby promoting tumor growth.
Zhaolei Cui, Chaoqiang Zheng, Yingying Lin, Zhenzhou Xiao, Yanhong Li, Wei Peng, Shijie He, Anyang Li, Xiufeng Wu, Yan Chen, Yang Sun   +10 more
wiley   +1 more source

Causal relationships between gut microbiota and urothelial carcinoma mediated by inflammatory cytokines and blood cell traits identified through Mendelian randomization analysis. [PDF]

Discov Oncol
Wu X, Zou W, Liu Z.
europepmc   +1 more source

Postoperative Prognostic Nutritional Index as a Useful Prognostic Factor in Patients With Gastric Cancer

Annals of Gastroenterological Surgery, EarlyView.
In patients after gastric cancer surgery, low postoperative PNI values, considering nutritional status, surgical stress, and postoperative inflammatory response, were significantly associated with poor prognosis in terms of both RFS and OS. ABSTRACT Aim To verify whether postoperative prognostic nutritional index is a useful prognostic factor in ...
Masaaki Yamamoto, Takeshi Omori, Yasunori Masuike, Naoki Shinno, Hisashi Hara, Takahito Sugase, Takashi Kanemura, Atsushi Takeno, Motohiro Hirao, Hiroshi Miyata   +9 more
wiley   +1 more source

PRMT1 promotes immune escape in hepatocellular carcinoma by regulating arginine methylation modification of MYC protein. [PDF]

Epigenetics
Zhou H, Wang Y, Wang D, Zhang M, Wang K, Liu C.   +5 more
europepmc   +1 more source

Integrating Immune Checkpoint Inhibitors With Total Neoadjuvant Therapy in Proficient Mismatch Repair Rectal Cancer

Annals of Gastroenterological Surgery, EarlyView.
The key to unlocking ICI benefit in pMMR/MSS LARC is to convert “cold” tumors into “hot” ones through lymphocyte‐sparing SCRT and judicious chemotherapy, creating a milieu in which ICIs can act effectively. ABSTRACT The management of locally advanced rectal cancer (LARC) has evolved with the adoption of total neoadjuvant therapy (TNT), integrated ...
Yoshinori Kagawa, Jun Watanabe, Koji Ando, Caleah Kitchens, Aron Bercz, J. Joshua Smith   +5 more
wiley   +1 more source

The DCDC2/ENO1 axis promotes tumor progression and immune evasion in intrahepatic cholangiocarcinoma via activating FGL1-LAG3 checkpoint. [PDF]

J Exp Clin Cancer Res
Wan W, Li Y, Sun W, Cheng Z, Ma F, Shen S, Liu H, Zhang J.   +7 more
europepmc   +1 more source

Target - The Elderly: A Nondiscrimination Perspective on Daniel Callahan\u27s Setting Limits [PDF]

, 1992
Destro, Robert A.
core   +1 more source

Harnessing the Biological Responses Induced by Nanomaterials for Enhanced Cancer Therapy

Aggregate, EarlyView.
Nanomaterial (NM)‐induced toxicity can be strategically repurposed for cancer therapy. This review summarizes the mechanism by which NMs selectively activate specific cellular processes to regulate cell fate independently. We also discussed how NMs‐induced biological responses can be leveraged as therapeutic strategies for cancer treatment.
Liting Wang, Hao Fu, Jiangtao Lin, Meng Zhao, Chuanrong Chen, Hongze Liao, Yourong Duan   +6 more
wiley   +1 more source