Results 61 to 70 of about 881,623 (280)

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Existence and uniqueness of positive even homoclinic solutions for second order differential equations

Electronic Journal of Qualitative Theory of Differential Equations, 2019
This paper is concerned with the existence of positive even homoclinic solutions for the $p$-Laplacian equation \begin{equation*} (|u'|^{p-2}u')' - a(t)|u|^{p-2}u+f(t,u)=0,\qquad t\in \mathbb{R}, \end{equation*} where $p\ge 2$ and the functions $a ...
Adel Daouas, Monia Boujlida
doaj   +1 more source

Integration by parts and Pohozaev identities for space-dependent fractional-order operators

, 2016
Consider a classical elliptic pseudodifferential operator $P$ on ${\Bbb R}^n$ of order $2a ...
Grubb, Gerd
core   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Differential equations of even-order with p-Laplacian like operators: qualitative properties of the solutions

Advances in Difference Equations, 2021
In this paper, we study the oscillation of solutions for an even-order differential equation with middle term, driven by a p-Laplace differential operator of the form { ( r ( x ) Φ p [ z ( κ − 1 ) ( x ) ] ) ′ + a ( x ) Φ p [ f ( z ( κ − 1 ) ( x ) ) ] + ∑
Omar Bazighifan, Thabet Abdeljawad, Qasem M. Al-Mdallal   +2 more
doaj   +1 more source

Oscillation of the even - order delay linear differential equation [PDF]

Carpathian Journal of Mathematics, 2015
In the paper we offer criteria for oscillation of the even order delay differential equation y(n)(t) + p(t)y(ct) = 0 We provide detail analysis of the properties of this equation, we offer necessary and sufficient conditions for oscillation of studied equation and we fulfill the gap in the oscillation theory.
J. DZURINA, B. BACULIKOVA
openaire   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source