Results 61 to 70 of about 14,986,562 (279)

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Existence of periodic solutions for a class of even order differential equations with deviating argument

Electronic Journal of Qualitative Theory of Differential Equations, 2009
Using Mawhin's continuation theorem we establish the existence of periodic solutions for a class of even order differential equations with deviating argument.
Chengjun Guo, Donal O'Regan, Yuantong Xu, Ravi Agarwal   +3 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

On a class of partial differential equations of even order

Annali di Matematica Pura ed Applicata, 1955
The general solution for a class of equations of even order is expressed as a sum of solutions of equations of second order.
openaire   +2 more sources

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Oscillation results for even-order quasilinear neutral functional differential equations

Electronic Journal of Differential Equations, 2011
In this article, we use the Riccati transformation technique and some inequalities, to establish oscillation theorems for all solutions to even-order quasilinear neutral differential equation $$ Big(ig[ig(x(t)+p(t)x(au(t))ig)^{(n-1)}ig]^gammaBig)' +
Blanka Baculikova, Jozef Dzurina, Tongxing Li   +2 more
doaj  

A oscillation theorem for a class of even order neutral differential equations

Journal of Mathematical Analysis and Applications, 2002
The author considers the even-order neutral differential equation \[ {d^n\over dt^n} [x(t)+ h(t) x(t-\tau)]+ f(t, x(g(t)))= 0,\tag{1} \] where \(\tau> 0\), \(h\in C(\mathbb{R})\), \(g\in C[t_0,\infty) \lim_{t\to\infty} g(t)= \infty\), \(f\in C([t_0, \infty)\times \mathbb{R})\), \(uf(t, u)\geq 0\) for \((t,u)\in [t_0,\infty)\times \mathbb{R}\), and \(f ...
openaire   +1 more source