Results 91 to 100 of about 9,614,982 (288)
Tau acetylation at K331 has limited impact on tau pathology in vivo
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Time at home. Analysis of a day centre as a place of care for women experiencing severe precarity
This article examines the role of spatial arrangements in care relations within a day centre for women experiencing severe precarity and/or homelessness in the Brussels-Capital Region.
Susan Even
doaj +1 more source
Intruder states in even-even Te nuclei
Abstract We use a systematic analysis of experimental data for 112–128Te to provide evidence for existence of intruder excitations in 116–124Te. We augment our analysis with mixed configuration IBM-2 calculations and find good agreement between these calculations and both experimental energy-level systematics and transition rates.
Rikovska, J +3 more
openaire +2 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Oxfam has partnered with the Poetry Society's Young Poets Network to give young people the opportunity to make their voices heard on global and gender inequality issues.
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Politisk og religiøs identitet blant kurdere i det syriske Jazira
Kurderes svar til Assad-regimets diskriminering og ekskluderende politiske strukturer, splitter det syrisk-kurdiske samfunnet.
Even Nord Rydningen
doaj +1 more source
Statistics of 2+ levels in even–even nuclei
Utilizando toda la información empírica disponible, analizamos las distribuciones de espaciado de los niveles 2+ de baja altitud de los núcleos pares. Para obtener muestras estadísticamente relevantes, los núcleos se agrupan en clases definidas por la relación R4/2 de las energías de excitación de los primeros 4+ y 2+ niveles.
Abul-Magd, A. +3 more
openaire +3 more sources
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Betongbyråkratiet: Den arkitektoniske arva etter norske rådhus frå etterkrigstida
Fleirtalet av norske rådhus frå etterkrigstida har klare fellestrekk: Dei var store i skala, bygd i betong og sentrale i samfunnsutviklinga – og dei fleste er framleis i bruk. Med basis i verneteoretiske perspektiv som vern gjennom bruk og eksperimentell
Even Smith Wergeland
doaj +1 more source

