Results 61 to 70 of about 16,356,505 (288)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

On the number of even latin squares of even order

open access: yes, 2020
We recall the Alon-Tarsi conjecture on the number of even latin squares. We introduce a map which switches the parity of a latin square under certain requirements. An example is included.
openaire   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Even order snake resonances [PDF]

open access: yesProceedings of International Conference on Particle Accelerators, 2002
We found that the perturbed spin tune due to the imperfection resonance plays an important role in beam depolarization at snake resonances. We also found that even order snake resonances exist in the overlapping intrinsic and imperfection resonances. Due to the perturbed spin tune shift of imperfection resonances, each snake resonance splits into two. >
openaire   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

Oscillatory criteria of noncanonical even-order differential equations with a superlinear neutral term

open access: yesBoundary Value Problems
The oscillatory behavior of solutions of an even-order differential equation with a superlinear neutral term is considered using Riccati and generalized Riccati transformations, the integral averaging technique, and the theory of comparison.
A. A. El-Gaber
doaj   +1 more source

Lower and Upper Solutions for Even Order Boundary Value Problems

open access: yesMathematics, 2019
In this paper, we prove the existence of solutions of nonlinear boundary value problems of arbitrary even order using the lower and upper solutions method.
Alberto Cabada, Lucía López-Somoza
doaj   +1 more source

On Buekenhout-Metz unitals of even order

open access: yesEuropean Journal of Combinatorics, 1992
A unital is a \(2-(n^ 3+1,n+1,1)\) design. The classical example of a unital is the set of absolute points in a projective plane \(\text{PG}(2,n^ 2)\) with respect to a unitary polarity, blocks being the sets of points on secant lines. A class of unitals, including the classical ones, can be constructed inside \(\text{PG}(2,n^ 2)\) by a method due to ...
openaire   +1 more source

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