Results 271 to 280 of about 312,730 (296)

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

The Owls Are Not What They Seem: Health, Mood, and Sleep Problems Reported by Morning and Evening Types with Atypical Timing of Weekend Sleep. [PDF]

Clocks Sleep
Putilov AA, Verevkin EG, Sveshnikov DS, Bakaeva ZV, Yakunina EB, Mankaeva OV, Torshin VI, Trutneva EA, Lapkin MM, Lopatskaya ZN, Budkevich RO, Budkevich EV, Ligun NV, Puchkova AN, Dorokhov VB.   +14 more
europepmc   +1 more source

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

FEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq, Nestor G. Casillas‐Vega, Alma Gomez‐Loredo, Xristo Zarate   +3 more
wiley   +1 more source

Using Machine Learning for the Discovery and Development of Multitarget Flavonoid-Based Functional Products in MASLD. [PDF]

Molecules
Kuznetsov M, Klein E, Velina D, Mutallibzoda S, Orlovtseva O, Tefikova S, Klyuchnikova D, Nikitin I.   +7 more
europepmc   +1 more source

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

Personalizing chronotherapy of immune checkpoint blockade. [PDF]

J Immunother Cancer
Ismail-Sutton S, Hughes B, Buchwald ZS, Wreglesworth NI, Dallmann R, Innominato PF.   +5 more
europepmc   +1 more source

Neural Correlates of Restless Legs Syndrome (RLS) Based on Electroencephalogram (EEG)-A Mechanistic Review. [PDF]

Int J Mol Sci
Chmiel J, Kurpas D.
europepmc   +1 more source

Circadian nutrition and obesity: timing as a nutritional strategy. [PDF]

J Health Popul Nutr
Alum EU.
europepmc   +1 more source

Dwarf Mongooses Lose Body Mass in Hot Weather due to Limited Behavioural Plasticity. [PDF]

Ecol Evol
Vane LS, Arbon JJ, Morris-Drake A, Kern JM, Radford AN.   +4 more
europepmc   +1 more source