Results 41 to 50 of about 108,897 (285)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács   +8 more
wiley   +1 more source

Detecting adaptive evolution in phylogenetic comparative analysis using the Ornstein-Uhlenbeck model

open access: yes, 2015
Phylogenetic comparative analysis is an approach to inferring evolutionary process from a combination of phylogenetic and phenotypic data. The last few years have seen increasingly sophisticated models employed in the evaluation of more and more detailed
Butler, Marguerite A.   +2 more
core   +2 more sources

Spatial and temporal variation in crop diversity in agroforestry homegardens of southern Ethiopia [PDF]

open access: yes, 2001
A key assumption in many homegarden studies is that homegardens are ecologically and socio-economically sustainable due to their species diversity. The precise relation between diversity and sustainability is still heavily debated, however.
Allahabadia, Amit   +7 more
core   +1 more source

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson   +3 more
wiley   +1 more source

DECODING MICROBIOME DYSBIOSIS THROUGH METAGENOMIC ALPHA DIVERSITY

open access: yesProblems of Infectious and Parasitic Diseases
Background: Sarcoidosis is a chronic inflammatory disease that can affect multiple organs. The aetiology of sarcoidosis is not fully understood, but there is increasing evidence that the microbiome may play a role.
Yordan Hodzhev   +7 more
doaj   +1 more source

Diversity and temporal dynamics of the epiphytic bacterial communities associated with the canopy-forming seaweed Cystoseira cornpressa (Esper) Gerloff and Nizamuddin [PDF]

open access: yes, 2016
Canopy-forming seaweed species of the genus Cystoseira form diverse and productive habitats along temperate rocky coasts of the Mediterranean Sea. Despite numerous studies on the rich macrofauna and flora associated with Cystoseira spp., there is little ...
Anne eWillems   +5 more
core   +3 more sources

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski   +9 more
wiley   +1 more source

Determination of Optimum Twist Equation for the Long Staple Combed Cotton Ring-Spun Yarn

open access: yesFibers, 2020
The aim of this research was to determine the optimum twist equation for ring-spun yarns. The yarn twist can be calculated by different equations.
Dunja Šajn Gorjanc, Neža Sukič
doaj   +1 more source

Growth Forms and Functional Guilds Distribution of Soil Fungi in Coastal Versus Inland Sites of Victoria Land, Antarctica

open access: yesBiology, 2021
In Victoria Land, Antarctica, ice-free areas are restricted to coastal regions and dominate the landscape of the McMurdo Dry Valleys. These two environments are subjected to different pressures that determine the establishment of highly adapted fungal ...
Fabiana Canini   +7 more
doaj   +1 more source

Microbial community changes induced by Managed Aquifer Recharge activities: linking hydrogeological and biological processes [PDF]

open access: yes, 2019
Managed Aquifer Recharge (MAR) is a technique used worldwide to increase the availability of water resources. We study how MAR modifies microbial ecosystems and its implications for enhancing biodegradation processes to eventually improve groundwater ...
Barba Ferrer, Maria del Carme   +6 more
core   +2 more sources

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