Results 231 to 240 of about 27,084,584 (305)

Disrupted Top-Down Modulation as a Mechanism of Impaired Multisensory Processing in Autistic Children. [PDF]

Adv Sci (Weinh)
Vanneau T, Foxe JJ, Beker S, Molholm S.
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Monolithic three-dimensionally integrated memristor-thin-film transistor for electrically programmable multimode reservoir computing. [PDF]

Nat Commun
Shim SK, Choi W, Cheong S, Shin DH, Shin J, Han J, Im J, Kim S, Son K, Kim HW, Kim JH, Cho JM, Park J, Park B, Jang YH, Hwang CS.   +15 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Relationship extraction for adverse drug events in clinical notes using large language models: a retrospective cross-sectional study. [PDF]

EBioMedicine
Plasek JM, Li Y, Amato MG, Foer D, Seger DL, Alzaidi S, Zhou H, Jackson GP, Bates DW, Zhou L.   +9 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Single-device in-sensor computing for multi-channel multiply-accumulate operations. [PDF]

Nat Commun
Wang M, Yu H, Wang B, Xu Z, Cai Z, Huang C, Zhao N.   +6 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

NeuroMimicNet: A Multimodal Neuromorphic Framework for Early Screening and Cognitive Pattern Recognition in Children with Autism. [PDF]

J Multidiscip Healthc
S P, R E.
europepmc   +1 more source