Results 91 to 100 of about 398,456 (338)

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Curiosity cloning: neural analysis of scientific knowledge [PDF]

, 2009
Event-related potentials (ERPs) are indicators of brain activity related to cognitive processes. They can be de- tected from EEG signals and thus constitute an attractive non-invasive option to study cognitive information pro- cessing.
Ampatzis, Christos, Ebrahimi, Touradj, Healy, Graham, Izzo, Dario, Rossini, Luca, Ruciński, Marek, Smeaton, Alan F., Wilkins, Peter, Yazdani, Ashkan   +8 more
core   +2 more sources

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

FEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen, Zenon Toprakcioglu, Michele Vendruscolo   +2 more
wiley   +1 more source

Event-related brain potentials (ERP): an overview

Revista Linguística, 2015
This text offers a practical overview of biological and technological aspects of an electromagnetic cognitive assessment tool named Event-Related Brain Potential (ERP), focusing on its application to language research.
Aline Gesualdi Manhães, Aniela Improta França   +1 more
doaj  

Attentional modulation of orthographic neighborhood effects during reading: Evidence from event-related brain potentials in a psychological refractory period paradigm [PDF]

, 2018
It is often assumed that word reading proceeds automatically. Here, we tested this assumption by recording event-related potentials during a psychological refractory period (PRP) paradigm, requiring lexical decisions about written words. Specifically, we
Conrad, Markus, Paschke-Goldt, Jörg, Rabovsky, Milena, Sommer, Werner, Álvarez, Carlos J.   +4 more
core   +1 more source

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

Hyperacusis questionnaire and event-related potential correlation in migraine patients

Scientific Reports
This study aims to investigate auditory hypersensitivity and cortical function in migraine patients using the Hyperacusis Questionnaire and the Event-Related Potential (ERP) technique.
Liu Qi, Zhang Jilei, Yu Lisheng, Jing Yuanyuan   +3 more
doaj   +1 more source

The multidrug and toxin extrusion (MATE) transporter DTX51 antagonizes non‐cell‐autonomous HLS1–AMP1 signaling in a region‐specific manner

FEBS Letters, EarlyView.
The Arabidopsis mutants hls1 hlh1 and amp1 lamp1 exhibit pleiotropic developmental phenotypes. Although the functions of the causative genes remain unclear, they act in the same genetic pathway and are thought to generate non‐cell‐autonomous signals.
Takashi Nobusawa, Makoto Kusaba
wiley   +1 more source

Reusable Multielectrode Array Technique for Electroencephalography in Awake Freely Moving Mice

Frontiers in Integrative Neuroscience, 2018
Translational comparison of rodent models of neurological and neuropsychiatric diseases to human electroencephalography (EEG) biomarkers in these conditions will require multisite rodent EEG on the skull surface, rather than local area ...
Carrie R. Jonak, Jonathan W. Lovelace, Jonathan W. Lovelace, Iryna M. Ethell, Iryna M. Ethell, Khaleel A. Razak, Khaleel A. Razak, Devin K. Binder, Devin K. Binder   +8 more
doaj   +1 more source

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source