Results 111 to 120 of about 398,456 (338)

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

open access: yesFEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer   +10 more
wiley   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

open access: yesFEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican   +7 more
wiley   +1 more source

The Analysis of Event-Related Potentials [PDF]

open access: yes, 2018
In this chapter, we provide an introduction to the major methods used for the analysis and classification of Event-Related Potentials (ERPs). We start by considering the problem of estimating ERP ensemble averages in the time domain. An estimator allowing for weights and time shifts for each trial is discussed.
openaire   +3 more sources

Novel and unscrutinized immune entities of the zebrafish gut

open access: yesFEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil   +5 more
wiley   +1 more source

Implicit detection of poetic harmony by the naïve brain

open access: yesFrontiers in Psychology, 2016
The power of poetry is universally acknowledged, but it is debatable whether its appreciation is reserved for experts. Here we show that readers with no particular knowledge of a traditional form of Welsh poetry unconsciously distinguish phrases ...
Awel Vaughan-Evans   +5 more
doaj   +1 more source

Error-related scalp potentials elicited by hand and foot movements : evidence for an output-independent error-processing system in humans

open access: yes, 1998
The error-related negativity (ERN) is a fronto-centrally distributed component of the event-related brain potential (ERP) that occurs when human subjects make errors in a variety of experimental tasks.
Coles, Michael G.H   +2 more
core   +1 more source

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

open access: yesFEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona   +4 more
wiley   +1 more source

Event-related brain potentials to typing errors in transparent and intransparent German words

open access: yesNeuroscience Research
Error detection in typing is crucial for assessing the adequacy of ongoing actions, leveraging both predictive mechanisms for early detection and sensory feedback for late detection.
Marcus Heldmann   +4 more
doaj   +1 more source

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