Results 81 to 90 of about 5,654,505 (287)

A Distance-Dependent Chinese Restaurant Process Based Method for Event Detection on Social Media

Inventions, 2018
In this paper, we propose a method for event detection on social media, which aims at clustering media items into groups of events based on their textural information as well as available metadata.
Georgios Palaiokrassas, Athanasios Voulodimos, Antonios Litke, Athanasios Papaoikonomou, Theodora Varvarigou   +4 more
doaj   +1 more source

Haploidentical Hematopoietic Cell Transplantation for Infants With X‐Linked Severe Combined Immunodeficiency Using Post‐Transplant Cyclophosphamide

Pediatric Blood &Cancer, EarlyView.
Shuhei Takahashi, Akito Kawachi, Dan Tomomasa, Eri Watanabe, Yuji Fujita, Yuya Sato, Masahiro Sekiguchi, Kentaro Watanabe, Moe Hidaka, Akihiro Hoshino, Takahiro Kamiya, Masatoshi Takagi, Hirokazu Kanegane, Motohiro Kato   +13 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Extrema-Triggered Conversion for Non-Stationary Signal Acquisition in Wireless Sensor Nodes

Journal of Low Power Electronics and Applications
While wireless sensor node (WSNs) have proliferated with the rise of the Internet of Things (IoT), uniformly sampled analog–digital converters (ADCs) have traditionally reigned paramount in the signal processing pipeline.
Swagat Bhattacharyya, Jennifer O. Hasler
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Event Detection and Identification of Influential Spreaders in Social Media Data Streams

Big Data Mining and Analytics, 2018
Microblogging, a popular social media service platform, has become a new information channel for users to receive and exchange the most up-to-date information on current events.
Leilei Shi, Yan Wu, Lu Liu, Xiang Sun, Liang Jiang   +4 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Applying a Machine Learning Method to Detect Changing Neuronal Activity in Seizure Disorders

Proceedings of the International Florida Artificial Intelligence Research Society Conference
This study aims to use machine learning to find miniature excitatory postsynaptic currents (EPSCs) in neurons of a Drosophila to find behavior markers of a seizure.
Cengiz Gunay, Krishan Bhalsod
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source