Results 41 to 50 of about 6,407,651 (267)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Composing Event-B Specifications - Case-Study Experience [PDF]
, 2011 Event-B is a formal method, based on set theory and first-order logic, for specification and verification of reactive systems supported by the Rodin tool kit.
Ali Gondal +5 more
core +2 more sources
Maximizing Asynchronicity in Event-based Neural Networks
CoRR22 pages, 7 figures, 15 tables, ICLR 2026 Camera Ready ...
Haiqing Hao +5 more
openaire +2 more sources
The legacy-factor: Towards conceptual clarification in the sport event context [PDF]
, 2009 Public policy planners and event organisers are increasingly promoting potential economic, tourism, social, and/or environmental legacies to justify significant investments required to host special events.
Schlenker, K +2 more
core
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Efficient Discovery of Compact Maximal Behavioral Patterns from Event Logs
International Conference on Advanced Information Systems Engineering, 2019 Techniques for process discovery support the analysis of information systems by constructing process models from event logs that are recorded during system execution.
Mehdi Acheli +2 more
semanticscholar +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
Generalized event-chain Monte Carlo: constructing rejection-free global-balance algorithms from infinitesimal steps. [PDF]
Journal of Chemical Physics, 2013 In this article, we present an event-driven algorithm that generalizes the recent hard-sphere event-chain Monte Carlo method without introducing discretizations in time or in space.
Manon Michel, S. Kapfer, W. Krauth
semanticscholar +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source