Results 81 to 90 of about 1,573,388 (253)

CRISPR targeting of FOXL2 c.402C>G mutation reduces malignant phenotype in granulosa tumor cells and identifies anti‐tumoral compounds

Molecular Oncology, EarlyView.
FOXL2 c.402C>G mutation drives granulosa cell tumors. Using CRISPR technology, we selectively corrected this mutation, reducing malignancy and increasing sensitivity to dasatinib and ketoconazole. Transcriptomic changes revealed potential therapeutic targets, demonstrating CRISPR's promise for treating this rare ovarian cancer.
Sandra Amarilla‐Quintana, Paloma Navarro, Iván Hernández, Alejandra Ramos, Ana Montero‐Calle, Pablo Cabezas‐Sainz, Maria J Barrero, Diego Megías, Borja Vilaplana‐Martí, Carolina Epifano, Déborah Gómez‐Dominguez, Sara Monzón, Isabel Cuesta, Laura Sánchez, Rodrigo Barderas, Jesús García‐Donas, Alberto Martín, Ignacio Pérez de Castro   +17 more
wiley   +1 more source

Requirements on common solutions to the LSND and MiniBooNE excesses: a post-MicroBooNE study

Journal of High Energy Physics, 2022
The strong statistical significance of an observed electron-like event excess in the MiniBooNE (MB) experiment, along with an earlier similar excess seen in the Liquid Scintillator Neutrino Detector (LSND), when interpreted in conjunction with recent ...
Waleed Abdallah, Raj Gandhi, Samiran Roy
doaj   +1 more source

Trans-Planckian physics and signature change events in Bose gas hydrodynamics [PDF]

, 2007
We present an example of emergent spacetime as the hydrodynamic limit of a more fundamental microscopic theory. The low-energy, long-wavelength limit in our model is dominated by collective variables that generate an effective Lorentzian metric.
A. D. Sakharov, A. D. Sakharov, Angela White, C. Barceló, C. J. Pethick, D. Mattingly, G. E. Volovik, M. Novello, Matt Visser, N. D. Birrell, R. M. Wald, Silke Weinfurtner, T. Dray, Y. Castin   +13 more
core   +2 more sources

PYTHIA 6.4 Physics and Manual [PDF]

, 2006
The Pythia program can be used to generate high-energy-physics ''events'', i.e. sets of outgoing particles produced in the interactions between two incoming particles.
T. Sjostrand, S. Mrenna, P. Skands
semanticscholar   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

Persistent homology of collider observations: When (w)hole matters

Physics Letters B, 2023
Topological invariants have played a fundamental role in the advancement of theoretical high energy physics. Physicists have used several kinematic techniques to distinguish new physics predictions from the Standard Model (SM) of particle physics at ...
Jyotiranjan Beuria
doaj  

Modelling substorm chorus events in terms of dispersive azimuthal drift [PDF]

Annales Geophysicae, 2004
The Substorm Chorus Event (SCE) is a radio phenomenon observed on the ground after the onset of the substorm expansion phase. It consists of a band of VLF chorus with rising upper and lower cutoff frequencies.
A. B. Collier, A. B. Collier, A. R. W. Hughes   +2 more
doaj   +1 more source

Porting HEP Parameterized Calorimeter Simulation Code to GPUs

Frontiers in Big Data, 2021
The High Energy Physics (HEP) experiments, such as those at the Large Hadron Collider (LHC), traditionally consume large amounts of CPU cycles for detector simulations and data analysis, but rarely use compute accelerators such as GPUs.
Zhihua Dong, Heather Gray, Heather Gray, Charles Leggett, Meifeng Lin, Vincent R. Pascuzzi, Kwangmin Yu   +6 more
doaj   +1 more source

Acacetin reduces endoplasmic reticulum stress through the P‐eNOS/PERK signaling pathway to attenuate MGO‐induced vascular endothelial cell dysfunction

FEBS Open Bio, EarlyView.
We investigated a potential protective effect of acacetin, a naturally occurring flavonoid, against methylglyoxal (MGO)‐induced endothelial dysfunction in human umbilical vein endothelial cells and its mechanism of action. Acacetin can could inhibit MGO‐induced intracellular calcium ion influx, enhance the expression levels of phosphorylated ...
Zhen Zhang, Kaien Hu, Zhaohui Fang, Sihai Wang, Jie Chen, Dengke Yin, Caiyun Zhang, Gefei Ma   +7 more
wiley   +1 more source