Results 111 to 120 of about 6,403,842 (262)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Report to the President for year ended June 30, 2019, Institute Events
, 2019 This report contains the following sections: Community and Special Events; Events and Information Center; Community Services Office; MIT Conference ...
Gallagher, Gayle M.
core
Committee on Community Events Minutes September 8, 2020 [PDF]
, 2020 Minutes for the meeting of the Committee on Community Events on September 8 ...
Bronx Community College Committee on Community Events
core
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Committee on Community Events Minutes October 13, 2020 [PDF]
, 2020 Minutes for the meeting of the Committee on Community Events on October 13 ...
Bronx Community College Committee on Community Events
core
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Committee on Community Events Minutes December 10, 2019 [PDF]
, 2019 Minutes for the meeting of the Committee on Community Events on November 21 ...
Bronx Community College Committee on Community Events
core
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Report to the President for year ended June 30, 2018, Institute Events
, 2018 This report contains the following sections: Community and Special Events; Events and Information Center; Community Services Office; MIT Conference ...
Gallagher, Gayle M.
core