Results 231 to 240 of about 6,403,842 (262)

The Systemic Lottery - A Field Observational Study on the Detection and Management of Acute Events in Care Homes. [PDF]

Scand J Caring Sci
Rudebeck TL, Nielsen D, Lassen AT, Andersen D, Østervang C.   +4 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Psychological resilience partially mediates the relationship between negative life events and suicidal ideation in Chinese adolescents. [PDF]

Front Psychiatry
Wu W, Liu L, Ishak Z, Wang Z, Sun J, Han Z.   +5 more
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

scASprofiler: profiling single-cell RNA splicing with a deep convolutional generative network. [PDF]

Brief Bioinform
Hu P, Song P, Dai B, Long C, Li H, Zuo Y, Xing Y.   +6 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Pharyngeal Residue Is Independently Associated With Mortality and Aspiration Events in Patients Undergoing Swallowing Assessment: A Retrospective Cohort Study. [PDF]

J Gen Fam Med
Chiko Y, Omote S, Miyasaka E.
europepmc   +1 more source

First-year all-cause kidney allograft loss: descriptive clinical trajectories of 92 events from a 17-year German transplant center cohort. [PDF]

BMC Nephrol
Jehn U, Lokschin A, Becker F, Houben P, Pavenstädt H, Reuter S.   +5 more
europepmc   +1 more source

Real-world safety profile of twice a day deferiprone in patients with thalassemia, sickle cell disease, or other anemias. [PDF]

Blood Adv
Sheth S, Lal A, Appiah-Kubi A, Peslak SA, Toiber Temin N, Chen MA, Coates T.   +6 more
europepmc   +1 more source

Event-Preserving Neural Network Denoising for Impedance Flow Cytometry. [PDF]

Nanomaterials (Basel)
Shi L, Jindrich C.
europepmc   +1 more source