Results 71 to 80 of about 6,403,842 (262)

The impact of strategic marketing elements on the customer relationship programme for a regional tourism organisation [PDF]

open access: yesThe Retail and Marketing Review, 2022
The article focuses on the impact of strategic marketing elements on the customer relationship program of the Tshwane Tourism Association (TTA) in South Africa.
Dr Malefane Stephen Monyane   +1 more
doaj  

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Preclinical evidence for supra-clinical acute kidney injury: current biomarkers are not enough

open access: yesIntensive Care Medicine Experimental
Background Acute kidney injury (AKI) is a frequent complication in hospitalized patients, affecting up to 50% of those in intensive care units (ICU). It is linked to high morbidity and mortality, with severity closely tied to patient outcomes.
Justine Serre   +7 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Special Events Planning

open access: yes, 1967
"The Special Events Committee is beginning to make plans for the remainder of the fall and the spring and is anxious to have some indication of what things both in particular and in general would be interesting and valuable ...
Special Events Committee
core  

Report to the President for year ended June 30, 2021, Institute Events

open access: yes, 2021
This report contains the following sections: Community and Special Events; Events and Information Center; Community Services Office; MIT Conference ...
Gallagher, Gayle M.
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The legacy of sport events: from a controlling approach to a strategic approach. The case of Giro d’Italia

open access: yes, 2009
The legacy of sport events: from a controlling approach to a strategic approach.
L. Macciò, RUTA, CATALDO
core  

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