Results 201 to 210 of about 1,940,060 (340)

Emotion regulation in everyday life: Mapping global self-reports to daily processes.

open access: green, 2022
Peter Koval   +7 more
openalex   +2 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Devotional Tools and Companions to Everyday Life:

open access: yesParse Journal
This essay explores the equivalence of various, occasionally contradictory and hybrid perceptions of materiality experienced in physical and non-physical contact.
Agnieszka Patała
doaj  

Effortful leisure is a source of meaning in everyday life. [PDF]

open access: yesCommun Psychol
Campbell AV   +3 more
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

The Everyday Life of Memorials

open access: yesPanorama
Martyna Ewa Majewska
doaj   +1 more source

Overactive Bladder and Its Impact on Everyday Life: A Qualitative Study. [PDF]

open access: yesCureus
Sigvard Fjord J   +3 more
europepmc   +1 more source

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