Results 181 to 190 of about 6,906,802 (378)

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Development of a Calculator For Medical Student Residency Applications [PDF]

, 2017
This poster describes an attempt to create an evidence-based approach to advising medical students with regard to the number of family medicine residency programs to which they need to ...
Crossman, Steven H.
core   +2 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

The COVID-19 pandemic: is our medicine still evidence-based? [PDF]

, 2020
Cristian Deana
openalex   +1 more source

Strengthening Evidence-based Family Medicine in Hong Kong [PDF]

, 2012
published_or_final_versio
Chen, JY, Chiu, BCF, Wong, WCW
core  

International Parkinson and movement disorder society evidence‐based medicine review: Update on treatments for the motor symptoms of Parkinson's disease

Movement Disorders, 2018
S. Fox, R. Katzenschlager, Shen-Yang Lim, B. Barton, R. D. de Bie, K. Seppi, M. Coelho, C. Sampaio   +7 more
semanticscholar   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

The evidence system of traditional Chinese medicine based on the Grades of Recommendations Assessment, Development and Evaluation framework

, 2017
Hao Chen, Wang Yan, Wenbo Jiang, Joey SW Kwong, Yi-Huang Gu   +4 more
openalex   +2 more sources

Effectiveness and safety of drugs for the treatment of gastroparesis: evidence-based medicine data. Review

, 2023
С. М. Ткач
openalex   +2 more sources

Attitudes of teachers to evidence based medicine

, 2004
AIM: To describe the attitudes of general practitioners and specialist clinical teachers toward teaching evidence based medicine (EBM). PARTICIPANTS AND METHODS: Questionnaire survey of 114 general practitioner and 162 specialist university teachers ...
Gilbert, Amanda, Kljakovic, Marjan, Love, Tom   +2 more
core