Results 201 to 210 of about 2,390,694 (316)

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

open access: yesMolecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen   +12 more
wiley   +1 more source

Artificial intelligence education: An evidence-based medicine approach for consumers, translators, and developers. [PDF]

open access: yesCell Rep Med, 2023
Ng FYC   +15 more
europepmc   +1 more source

Evidence-based medicine

open access: bronze, 1999
Giuseppe Mancia, Alberto Zanchetti
openalex   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

open access: yesMolecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu   +12 more
wiley   +1 more source

Common misunderstandings of evidence-based medicine. [PDF]

open access: yesHerzschrittmacherther Elektrophysiol, 2023
Semrau F, Aidelsburger P, Israel CW.
europepmc   +1 more source

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