Results 211 to 220 of about 4,688,320 (340)

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Investigating the knowledge attitude and practice of evidence based medicine education in Sudanese medical students: a cross sectional study. [PDF]

BMC Med Educ
Amin MHJ, Awad MH, Mohamed Ginawi ES, Mohammed ASK, Noureldaiem Ibrahim EHE, Yassen OYM, Elomeiri LESMA, Hakim Hussain AHMA, Eltahir TA, Mohmmed FSAA, Wedatalla RAE, Awad KH, Mahgoub RKE, Karar AMA, Saeed AYM, Mohamed AEA, Mohamed Ginawi RS, Sidar FMK, Saifalsorori RRA, Osman OIA, Nouri MAI, Mohamed MAA, Ibrahim NBM, Mohamed MMM, Mohamed AEAB, MohamedAhmed FMA, Hassan MRM, Mohamed SAA, Bashar Hadi HE, Gandour HMNG, Ahmed NAF, Ahmed NME, Osman MMAA, Elhadi SEI.   +33 more
europepmc   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Evidence based medicine: philosophical [PDF]

, 2003
Sehon, S., Stanley, Donald
core  

GLP-1 receptor agonist for weight loss and fertility: Social media and online perception versus evidence-based medicine. [PDF]

PLoS One
Merhi Z, Karekar M, Mouanness M.
europepmc   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Evidence-Based Medicine: <i>Knowledge, attitudes and practices among senior medical students and interns in Oman</i>. [PDF]

Sultan Qaboos Univ Med J
Al-Hadhrami RS, Al-Shaqsi AN, Thuhli ZMA, Sabbari MYA.   +3 more
europepmc   +1 more source

Single‐cell transcriptomics redefines focal neuroendocrine differentiation as a distinct prostate cancer pathology

Molecular Oncology, EarlyView.
Single‐cell transcriptomics of prostate cancer patient‐derived xenografts reveals distinct features of neuroendocrine (NE) subtypes. Tumours with focal NE differentiation (NED) share transcriptional programmes with adenocarcinoma, differing from large and small cell neuroendocrine prostate cancer (NEPC). Our work defines the molecular landscape of NEPC,
Rosalia Quezada Urban, Shivakumar Keerthikumar, Ashlee Clark, Hong Wang, Belinda Phipson, Andrew Bakshi, Andrew Ryan, Heather Thorne, Renea A. Taylor, Mitchell G. Lawrence, Gail P. Risbridger, Roxanne Toivanen, David L. Goode   +12 more
wiley   +1 more source

The impact of evidence-based medicine curricula on information literacy among clinical medical undergraduates and postgraduates in China. [PDF]

BMC Med Educ
Wang C, Yao Y, Chen Y, Chen J.
europepmc   +1 more source

The Application of Evidence-Based Medicine in Individualized Medicine. [PDF]

Biomedicines, 2023
Van de Vliet P, Sprenger T, Kampers LFC, Makalowski J, Schirrmacher V, Stücker W, Van Gool SW.   +6 more
europepmc   +1 more source