Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Crosstalk between cardiac dysfunction and outcome of liver cirrhosis: Perspectives from evidence-based medicine and holistic integrative medicine. [PDF]
J Transl Int MedDong L, Qi X, Wang H, Fan D.
europepmc +1 more source
Identifying prognostic targets in metastatic prostate cancer beyond AR
FEBS Open Bio, EarlyView.Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng +13 more
wiley +1 more source
Evidence-Based Medicine Culture, Curriculum, and Program Outcomes: A CERA Study. [PDF]
Fam MedRowland K +6 more
europepmc +1 more source
Evidence based medicine overviews, bulletins, guidelines, and the new consensus
, 2000 Rebecca West
openalex +1 more source
Current trends in single‐cell RNA sequencing applications in diabetes mellitus
FEBS Open Bio, EarlyView.Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian +6 more
wiley +1 more source
Digital health competences and AI beliefs as conditions for the practice of evidence-based medicine: a study of prospective physicians in Canada. [PDF]
Med Educ OnlineWagner G +3 more
europepmc +1 more source
The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity
FEBS Open Bio, EarlyView.We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Shou Soeda +9 more
wiley +1 more source
Care of Diabetes and the Sacrifice of Evidence-Based Medicine and Health Equity. [PDF]
J Gen Intern MedGoldberg D.
europepmc +1 more source
Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary
, 2000 K Mackway-Jones
openalex +1 more source