Results 291 to 300 of about 6,906,802 (378)

Navigating new norms: a systematic review of factors for the development of effective digital tools in higher education

FEBS Open Bio, EarlyView.
What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman, Jessica Haines, Connie Pritchard, Stephen Rutherford, Nigel Francis   +4 more
wiley   +1 more source

The impact of evidence-based medicine curricula on information literacy among clinical medical undergraduates and postgraduates in China. [PDF]

BMC Med Educ
Wang C, Yao Y, Chen Y, Chen J.
europepmc   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

"I still have not mastered that skill!" Medical student perspectives on a simulation-based evidence-based medicine competency assessment. [PDF]

J Med Libr Assoc
Nicholson J, Plovnick C, Magro J, van der Vleuten C, de Bruin A, Kalet A.   +5 more
europepmc   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

[Medical Practice, Epidemiology, and Evidence-Based Medicine: A necessary triangle in healthcare]. [PDF]

Rev Med Inst Mex Seguro Soc
Vallejos-Parás A, Cabrera-Gaytán DA, Hernández-Bautista PF, Jaimes-Betancourt L, Cruz-Orozco O, Valle-Alvarado G.   +5 more
europepmc   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

Diagnostic and therapeutic management of severe acute pancreatitis. Evidence based medicine (EBM) clinical practice guidelines. [PDF]

Wideochir Inne Tech Maloinwazyjne
Szeliga J, Jagielski M, Sobocki J, Borys M, Czuczwar M, Durczyński A, Gach T, Hogendorf P, Kawiński A, Kuśnierz K, Major P, Mik M, Pędziwiatr M, Piwowarczyk P, Sierżęga M, Spychalski M, Szczeklik W, Szura M, Wierdak M, Zgodziński W, Budzyński A, Hać S, Jackowski M, Kielan W, Kukla M, Mrowiec S, Myśliwiec P, Sieńko J, Słodkowski M, Tarnowski W, Wallner G, Zawadzki M, Zieniewicz K.   +32 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Reevaluating Mask Effectiveness: Insights From Evidence-Based Medicine and Clinical Trials. [PDF]

Cureus
Spira B.
europepmc   +1 more source