Results 91 to 100 of about 961,861 (304)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Integrating quality improvement, evidence-based practice, and knowledge translation into a health Sciences masters’ programme: a mixed methods study

BMC Medical Education
Background In recent years, the emphasis on quality improvement (QI), evidence-based practice (EBP), and knowledge translation (KT) in the education of health professionals has increased.
Per Koren Solvang, Jan Egil Nordvik, Anders Vege, Hilde Tinderholt Myrhaug   +3 more
doaj   +1 more source

Prescription practices in the outpatient department of Bangladesh Medical University: A clinical audit

Bangabandhu Sheikh Mujib Medical University Journal
Not ...
Kazi Ali Aftab, Khaled Mahbub Murshed, Abdullah Al Faisal, Md. Hashibul Hasan Shawon, Tasnim Nafian, Md. Abul Kalam Azad, Shahinul Alam   +6 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Effectiveness of a Technology-Based Intervention to Teach Evidence-Based Practice: The EBR Tool

, 2016
Background As the world becomes increasingly digital, advances in technology have changed how students access evidence-based information. Research suggests that students overestimate their ability to locate quality online research and lack the skills ...
Song, Huaxin, Zeeni, Nadine, Harrison, LaNell, White, Patricia, Ford, Cindy, Sukkarieh-Haraty, Ola, Proper, Sharlan, Gannaway, Paula, Byers, Beverly, Long, JoAnn D., Brown, Justin, Doumit, Rita, Milane, Aline, Hatch, Daniel   +13 more
core   +1 more source

Clinical Audits in Medical Education: Insights from a Cross-Sectional Study of Medical Students

International Journal of Medical Students
Background: Clinical audits are crucial for enhancing healthcare quality, but various obstacles can restrict their implementation. This study aims to examine barriers to the implementation of clinical audits among medical students and interns. Methods:
Mohammad Ghassab Deameh, Omar S Mansour, Hammam Abu Rahmeh, Baha’ Aldeen Bani Irshid, Mohammad Walid Da'meh, Enas A. Amaireh, Yazeed Badran, Jebreen A. Elaydi, Hasan M. Abu Obaideh, Suhaib Feras Fawarseh, Khaled Funjan   +10 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Quality Improvement in Stroke Care and Its Impact: the Georgia Coverdell Acute Stroke Registry Experience

, 2018
The Georgia Department of Public Health has been engaged in a registry-based quality improvement initiative to monitor and improve the quality of stroke care.
Ido, Moges
core   +1 more source

How to Choose the Best Evidence?

Acta Médica Portuguesa, 2018
N/A.
Pedro Escada
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source