Results 231 to 240 of about 763,555 (302)

Improving Heart Failure Quality of Care Over the First Twenty Years: The Get With the Guidelines-Heart Failure Program. [PDF]

Circ Heart Fail
Tang AB, Li S, Li Y, Zhao J, Thomas K, Lewsey SC, Heidenreich PA, Greene SJ, Allen LA, Jessup M, Bolles M, Rutan C, Navar N, Yancy CW, Fonarow GC.   +14 more
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

A comparative analysis of health technology assessment decision-making for cancer drugs in Germany and England. [PDF]

Front Public Health
He J, Wei H, Mo Q, Liu Y, Li X, Yang Y, Tian L.   +6 more
europepmc   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Digital health technologies in pain management for patients with endometriosis: A scoping review. [PDF]

PLoS One
Wang X, Wang H.
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

ELSO 2025 Narrative Guideline on ECMO Training and Continuing Education. [PDF]

ASAIO J
Moore EA, Han P, Shekar K, Ramanathan K, Riera Del Brio J, Puslecki M, Diaz R, Alfoudri H, Ramanan R, Sin SWC, Vercaemst L, Friedrich T, Roeleveld P, Said A, Alinier G, Zakhary B.   +15 more
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Exploring the Generalizability of Discharge Process Optimization: An Implementation Science Perspective. [PDF]

Glob J Qual Saf Healthc
Zhao D.
europepmc   +1 more source

Optimizing Outcomes Through Evidence-Based Protocols in Postoperative Intensive Care: Clinical Standards, Implementation Strategies, and Quality Improvement

Ashok Kumar*1, Nitin Kumar2, Mohini Dhabhai3
openalex   +1 more source