Results 91 to 100 of about 13,693,576 (308)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

A New Method to Identify Incomplete Frame of Discernment in Evidence Theory

IEEE Access, 2019
One assumption of Dempster–Shafer evidence theory (D–S theory) is the closed world. However, how to determine whether the frame of discernment is incomplete or not is still an open issue.
Renliang Sun, Yong Deng
semanticscholar   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Uncertainty measure based on Tsallis entropy in evidence theory

International Journal of Intelligent Systems, 2019
Dempster‐Shafer evidence theory has been widely used in many applications due to its advantages with weaker conditions than Bayes probability. How to measure the uncertainty of basic probability assignment (BPA) in Dempster‐Shafer evidence theory is an ...
Xiaozhuan Gao, Fan Liu, Lipeng Pan, Yong Deng, S. Tsai   +4 more
semanticscholar   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Volume Dimension of Mass Functions in Complex Networks

Mathematics
A novel definition of volume dimension for a mass function based on a sigmoid asymptote is proposed; in particular, we extend the volume dimension of a mass function to define the volume dimensions for nodes and edges in complex networks.
Maria del Carmen Soto-Camacho, Jazmin Susana De la Cruz-Garcia, Juan Bory-Reyes, Aldo Ramirez-Arellano   +3 more
doaj   +1 more source

A Novel Semi-Supervised Classification Method Based on Soft Evidential Label Propagation

IEEE Access, 2019
For semi-supervised learning, we propose the label propagation method in the framework of evidence theory. The proposed method can deal with two problems which are the classification tasks with extremely few labeled data and identification of outlier ...
Jintao Meng, Dongmei Fu, Yongchuan Tang, Tao Yang, Dawei Zhang   +4 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

A Self-Adaptive Dynamic Recognition Model for Fatigue Driving Based on Multi-Source Information and Two Levels of Fusion

Sensors, 2015
To improve the effectiveness and robustness of fatigue driving recognition, a self-adaptive dynamic recognition model is proposed that incorporates information from multiple sources and involves two sequential levels of fusion, constructed at the ...
Wei Sun, Xiaorui Zhang, Srinivas Peeta, Xiaozheng He, Yongfu Li, Senlai Zhu   +5 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source