Results 251 to 260 of about 11,039,070 (302)

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Evaluating GenAI‐produced feedback on undergraduate bioscience essays against good higher education feedback practice

FEBS Open Bio, EarlyView.
This pilot study investigates the potential of Generative AI to provide formative feedback to students. ChatGPT was prompted to provide feedback on Year 1 Bioscience essays, which were evaluated against established good feedback practices. GenAI‐authored feedback had useful elements, but was limited in scope. GenAI may have potential to provide instant,
Annabel Court, Nigel Francis, Andrew Shore, Stephen Rutherford   +3 more
wiley   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

In vitro generation of regulatory T cells: A challenging tool for studying immune aging in humans

FEBS Open Bio, EarlyView.
In vitro induction of human regulatory T cells using standard protocols generates suppressive, Foxp3‐expressing CD4+ T cells independently of TGF‐β supplementation and donor age. Regulatory T (Treg) cells play a key role in immune tolerance and homeostasis.
Lynn Muller, Jana Bleher, Birgit Weinberger, Lourdes Rocamora‐Reverte   +3 more
wiley   +1 more source

Determinants of undergraduate bioscience engagement: Validating attendance barriers and classroom spatial behaviour across institutions

FEBS Open Bio, EarlyView.
Student engagement extends beyond simple attendance. Across 891 bioscience students from three universities, attendance behaviour was associated mainly with structural influences, whereas classroom spatial behaviour reflected affective and sensory factors.
Nigel Page, Rachel J. Hunt, Lauren J. Albee, Daniel Berwick, Alison Snape   +4 more
wiley   +1 more source

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On Nursing Theories and Evidence

Journal of Nursing Scholarship, 2001
Purpose: To expand the understanding of what constitutes evidence for theory‐guided, evidence‐based nursing practice from a narrow focus on empirics to a more comprehensive focus on diverse patterns of knowing.Organizing construct: Carper's four fundamental patterns of knowing in nursing—empirical, ethical, personal, and aesthetic—are required for ...
J, Fawcett, J, Watson, B, Neuman, P H, Walker, J J, Fitzpatrick   +4 more
openaire   +2 more sources

On the evidence inference theory

Information Sciences, 1996
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Yong-Ge Wu, Jing-Yu Yang 0001, Ke Liu, Lei-Jian Liu   +3 more
openaire   +3 more sources

Debt-Deflation: Theory and Evidence [PDF]

European Economic Review, 1994
Over the years 1989-92 many of the major industrialised countries have experienced protracted periods of below-trend growth, and some the longest recession since the 1930s. And the most severe recessions occurred in those countries which had experienced the largest increases in private debt burdens. Figure 5.1 illustrates this correlation for ten major
openaire   +1 more source

The Rough Sets Theory and Evidence Theory

Fundamenta Informaticae, 1990
The aim of the paper is to show some connections between the rough sets theory and the Dempser-Shafer approach. We prove that for every Pawlak’s approximation space there exists a Dempster-Shafer space with the qualities of the lower and upper approximations of sets in the approximation space equal to the credibility and plausibility of sets in the ...
openaire   +2 more sources