Results 51 to 60 of about 721,764 (290)
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács +8 more
wiley +1 more source
Cerâmica de tradição islâmica em contexto português
The excessive tutelage of Political History over the study of medieval materials, frequently results in attempts to link directly the archeological record with an historical conjuncture, generally disruptive.
Marco Liberato +11 more
doaj +1 more source
Absence of evidence is not evidence of absence [PDF]
We need to report uncertain results and do it clearly The title of this editorial is not new. For example, it was used nearly a decade ago for an article in the BMJ 's Statistics Notes series.1 Altman and Bland considered the dangers of misinterpreting differences that do not reach significance, criticising use of the term “negative” to describe ...
openaire +2 more sources
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait +23 more
wiley +1 more source
“Unless I am convinced by Sacred Scripture or by evident reason, I will not recant. My conscience is held captive by the Word of God and to act against conscience is neither right nor safe.” Kata-kata ini diucapkan oleh Martin Luther pada 18 April 1521 ...
Yohanes Adrie Hartopo
doaj +1 more source
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson +3 more
wiley +1 more source
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski +9 more
wiley +1 more source
Oscillons: an encounter with dynamical chaos in 1953?
We present evidences that Ben F. Laposky (1914-2000) might have been the first person who created a family of nonlinear analog circuits that allowed him to observe chaotic attractors and other trademarks of nonlinear science as early as 1953.Comment ...
A. V. Ponomarev +9 more
core +1 more source
ABSTRACT Purpose Although not always achieved, complete chemotherapy‐induced nausea and vomiting (CINV) control is the conventional goal of CINV prophylaxis. In this two‐center, mixed‐methods study, we sought to understand the preferences of adolescent patients and family caregivers for CINV control endpoints.
Haley Newman +8 more
wiley +1 more source

