The sophist in the server : Rhetoric, Reasoning and Scientific Judgment in the Age of LLMs. [PDF]
EMBO RepColangelo MT, Galli C.
europepmc +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Facing Openness with Socio Cognitive Trust and Categories.
Typical solutions for agents assessing trust relies on the circulation of information on the individual level, i.e. reputational images, subjective experiences, statistical analysis, etc.
Castelfranchi, Cristiano +3 more
core
The DSM validation method and its decision points: value judgments, metaphysical presuppositions, and validators. [PDF]
Hist Philos Life SciRodríguez Puente A.
europepmc +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Adaptive Fuzzy Evidential Reasoning for Automated Brain Tissue Segmentation
, 2004 This paper presents an adaptive fuzzy evidential reasoning approach, for segmenting multi-modality MR brain images. A novel fuzzy evidence structure model is proposed under the assumption that each information source provides two types of evidence ...
Hongwei Zhu, Otman Basir
core
Backbone agnostic Pareto evidential networks for trustworthy fault diagnosis and out of distribution detection. [PDF]
Sci RepShi J, Tang M, Tan L.
europepmc +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
A novel diffuse liver nodule detector via integrating semantic edge features and probabilistic uncertainty modeling. [PDF]
Front Artif IntellTian L, Liu X, Shi Y, Ji Y, Wang S.
europepmc +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source