Results 111 to 120 of about 11,003 (291)
, 2011 Evidentiality is a grammatical category with source of information as its primary meaning—whether the speaker saw the event happen, did not see it but heard it, made an inference based on general knowledge or visual traces, or was told about it. Languages may distinguish firsthand and nonfirsthand information or have a special marker just for reported ...
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Yauyos Quechua Evidentials And Evidential Modifiers
, 2012 This paper examines the evidential system of the five southern dialects of Yauyos, a previously undocumented, extremely endangered Quechuan language of Peru. The paper looks at Yauyos' unusual system of evidential modification and its effects on the interpretation of mode, particularly in conjunction with the language's ...
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FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Antiracist Documentation Practices - Shaping Clinical Encounters and Decision Making. [PDF]
N Engl J Med, 2023 Williams JC +8 more
europepmc +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source