Results 61 to 70 of about 771,683 (301)

BGN/MDK Axis in the Melanoma Tumor Microenvironment Strengthens Tumor Malignancy by Modulating Cancer Cells and Cancer‐Associated Fibroblasts Crosstalk

open access: yesAdvanced Science, EarlyView.
This study reveals that m6A regulators cooperatively upregulate BGN in melanoma, promoting malignancy. Within the tumor microenvironment, CAFs show highest BGN expression. The BGN/MDK axis mediates cancer‐stroma crosstalk, driving normal fibroblast (NF) activation and enhancing the pro‐tumor effect of CAFs, highlighting a promising therapeutic target ...
Hao‐ze Shi   +16 more
wiley   +1 more source

Can we choose evil? A discussion of the problem of radical evil as a modern and ancient problem of freedom [PDF]

open access: yes, 2004
The problem discussed in this paper emerges from work I’ve\ud done on the modern ideal of autonomy.1 I found that autonomy is often\ud seen as a morally neutral term.
Coeckelbergh, Mark
core   +1 more source

Decoding Triphenotypic Neutrophils in Cervical Cancer Evolution and Targeting SPP1+/GBP1+/ELOVL5+ Tumor‐Associated Neutrophils to Sensitize Immunotherapy

open access: yesAdvanced Science, EarlyView.
The functional schematic diagram of tumor associated neutrophils. Abstract Enhancing cervical cancer (CC) immunotherapy requires deciphering the heterogeneous tumor immune microenvironment (TIME), particularly neutrophil phenotypic dynamics. Here, 1) we collected 543 CC cases to find that patients with elevated neutrophil levels have a higher incidence
Xingyu Chang   +7 more
wiley   +1 more source

Process-Panentheism and the “Only Way” Argument

open access: yesOpen Theology, 2022
Given panentheism, when trying to offer a plausible solution to the problem of evil, what is the most promising way forward? In this article, I argue that a panentheist who wants to answer the problem of evil by using the “only way” argument should ...
Langby Lina
doaj   +1 more source

Internet Filter Use In ACL Libraries

open access: yes, 2000
Will Internet filters deliver us from evil or are they a necessary evil? Are Christian colleges using Internet filters? If so, which filters?
Sullivan, Diane
core   +1 more source

Mechanical Overloading‐Induced Nanomineral Crystal Perturbation from the Osteochondral Interface: A Potential Initiator of Osteoarthritis

open access: yesAdvanced Science, EarlyView.
Laser‐induced graphene (LIG) provides a scalable, laser‐direct‐written route to porous graphene architecture with tunable chemistry and defect density. Through heterojunction engineering, catalytic functionalization, and intrinsic self‐heating, LIG achieves highly sensitive and selective detection of NOX, NH3, H2, and humidity, supporting next ...
Nan Jiang   +8 more
wiley   +1 more source

On the Metaphysical Necessity of Suffering from Natural Evil [PDF]

open access: yes, 2013
Why does God permit suffering in the world? If God is wholly good, omnipotent, and omniscient, why would He not intervene to prevent us from suffering?
Sullivan, Ryan Edward
core   +1 more source

Reality and the Meaning of Evil: On the Moral Causality of Signs [PDF]

open access: yes, 2020
: “Evil is really only a privation.” This philosophical commonplace reflects an ancient solution to the problem of theodicy in one of its dimensions: is evil of such a nature that it must have God as its author?
Kanzelberger, Kirk G.
core   +1 more source

Hierarchical Targeting of TREM2+ Myeloid Cells via Acid‐Triggered OMVs Reprogram Immunosuppression and Suppress Osteolysis in Bone‐Metastatic TNBC

open access: yesAdvanced Science, EarlyView.
This study developed a hierarchical targeting nanoplatform, siTREM2@ETP‐PEOz‐OMVs, against triple‐negative breast cancer (TNBC) bone metastasis. It precisely delivers therapeutic siTREM2 to monocytes/macrophages within the metastatic niche. This intervention dually regulates cell fate: reprogramming immunosuppressive macrophages and inhibiting ...
Fanglu Chen   +12 more
wiley   +1 more source

Karakter Ibu Tiri Selalu Jahat? (Studi Perbandingan Cerita Rakyat Indonesia)

open access: yesJurnal Sosial Humaniora, 2017
The story of the stepmother in almost all cultures often describes her as evil, ambitious, and cruel. This paper presents a comparative study of two Indonesian folklore that presents the theme of stepmother. Through a structural and sociological approach,
Aurelius Ratu
doaj   +1 more source

Home - About - Disclaimer - Privacy