Results 31 to 40 of about 41,154 (198)

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Photosynthesis under far‐red light—evolutionary adaptations and bioengineering of light‐harvesting complexes

FEBS Letters, EarlyView.
Phototrophs evolved light‐harvesting systems adapted for efficient photon capture in habitats enriched in far‐red radiation. A subset of eukaryotic pigment‐binding proteins can absorb far‐red photons via low‐energy chlorophyll states known as red forms.
Antonello Amelii, Edoardo Andrea Cutolo, Daniele Montepietra, Claudia Battarra, Roberto Caferri, Stefano Capaldi, Zeno Guardini, Luca Dall'Osto, Roberto Bassi   +8 more
wiley   +1 more source

Potencial evocado auditivo para diagnóstico de surdez bilateral em dois cães Auditory evoked potential to diagnose of bilateral deafness in two dogs

Ciência Rural, 2012
O potencial auditivo evocado de tronco encefálico é um método eletrodiagnóstico não invasivo que permite avaliação objetiva do estado auditivo, da orelha média ao tronco encefálico, captando a atividade elétrica do sistema auditivo, gerada a partir de um
Mariana Isa Poci Palumbo, Luiz Antonio de Lima Resende, Luiz Henrique de Araújo Machado, Alexandre Secorun Borges   +3 more
doaj   +1 more source

Attenuation of Hippocampal Evoked Potentials in vivo by Activation of GtACR2, an Optogenetic Chloride Channel

Frontiers in Neuroscience, 2021
AimGtACR2, a light-activated chloride channel, is an attractive tool for neural inhibition as it can shunt membrane depolarizations. In this study, we assessed the effect of activating GtACR2 on in vivo hippocampal CA1 activity evoked by Schaffer ...
Anirudh R. Acharya, Lars Emil Larsen, Wouter Van Lysebettens, Wytse Jan Wadman, Jean Delbeke, Kristl Vonck, Alfred Meurs, Paul Boon, Robrecht Raedt   +8 more
doaj   +1 more source

The role of fibroblast growth factors in cell and cancer metabolism

FEBS Letters, EarlyView.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source

Exploring the Mechanisms of Exercise-Induced Hypoalgesia Using Laser Evoked Potentials

Frontiers in Physiology, 2016
Exercise-induced hypoalgesia is well described, but the underlying mechanisms are unclear. The aim of this study was to examine the effect of exercise on somatosensory evoked potentials, laser evoked potentials, pressure pain thresholds and heat pain ...
Matthew David Jones, Matthew David Jones, Janet Louise Taylor, Janet Louise Taylor, John Booth, Benjamin Kenneth Barry, Benjamin Kenneth Barry   +6 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Observing nociceptive detection thresholds and evoked potentials in diabetic patients with and without painful neuropathy

Exploration of Neuroscience
Aim: Diabetic polyneuropathy is the most described complication in patients with diabetes mellitus. A significant percentage of these patients experience disabling neuropathic pain (painful diabetic polyneuropathy).
Tom Berfelo, Imre P. Krabbenbos, Boudewijn van den Berg, Silvano R. Gefferie, Jan R. Buitenweg   +4 more
doaj   +1 more source

Neurological Deficits among Beta-Thalassemia Patients and its Possible Therapeutic Intervention : A Comprehensive Review

Journal of the Dow University of Health Sciences, 2020
Beta-thalassemia is a genetico-haematological disorder that affects the integrity, structure, and survival of red blood cells due to deleterious mutation in the β-globulin chain of hemoglobin.
Fahad Hassan Shah, Jawaria Idrees, Syed Turab Ali Shah, Rimsha Khan, Affifa Tahir Khan, Saad Salman, Abid Ali Khan   +6 more
doaj   +1 more source